Acute Rhinosinusitis Among Pediatric Patients with Allergic Rhinitis: A Nationwide, Population-based Cohort Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2019 Feb 13

PMID 30753196

Citations 3

Authors

Shi-Wei Lin

Sheng-Kai Wang

Ming-Chi Lu

Chun-Lung Wang

Malcolm Koo

Affiliations

Soon will be listed here.

Abstract

Background: While chronic rhinosinusitis is a common complication of allergic rhinitis, the link between acute rhinosinusitis and allergic rhinitis is unclear. The aim of this study was to evaluate the risk of incident acute rhinosinusitis among pediatric patients with allergic rhinitis, using a nationwide, population-based health claims research database.

Methods: Newly diagnosed allergic rhinitis patients aged 5-18 years were identified from the health claim records of the Longitudinal Health Insurance Database 2000 of Taiwan's National Health Insurance Research Database. A comparison cohort was assembled by randomly selecting patients from the same database with frequency matching by sex, age group, and index year. All patients were followed until a diagnosis of acute rhinosinusitis or the end of the follow-up period. Cox proportional hazards model was used to assess the association between allergic rhinitis and acute rhinosinusitis.

Results: Of the 43,588 pediatric patients included in this study, 55.4% were male and 43.9% were between the ages of 5.0-7.9 years. The risk of acute rhinosinusitis was significantly higher in pediatric patients with allergic rhinitis compared to those without the condition (adjusted hazard ratio = 3.03, 95% confidence interval = 2.89-3.18). Similar hazard ratios were observed between male and female pediatric patients.

Conclusions: This secondary cohort study using a nationwide, population-based health claim data of the Taiwan's NHIRD showed that allergic rhinitis was significantly associated with a higher risk of acute rhinosinusitis among pediatric patients.

Citing Articles

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Clinical Evidence and Biomarkers Linking Allergy and Acute or Chronic Rhinosinusitis in Children: a Systematic Review.

De Corso E, Lucidi D, Cantone E, Ottaviano G, Di Cesare T, Seccia V Curr Allergy Asthma Rep. 2020; 20(11):68.

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Common Cold and Acute Rhinosinusitis: Up-to-Date Management in 2020.

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References

Foden N, Burgess C, Shepherd K, Almeyda R . A guide to the management of acute rhinosinusitis in primary care: management strategy based on best evidence and recent European guidelines. Br J Gen Pract. 2013; 63(616):611-3. PMC: 3809423. DOI: 10.3399/bjgp13X674620. View

Dykewicz M, Hamilos D . Rhinitis and sinusitis. J Allergy Clin Immunol. 2010; 125(2 Suppl 2):S103-15. DOI: 10.1016/j.jaci.2009.12.989. View

Marseglia G, Klersy C, Barberi S, Marseglia A, Castellazzi A, Pagella F . Antibiotic treatment alone for acute rhinosinusitis gives a poor response in allergic children. Int J Immunopathol Pharmacol. 2007; 20(1):97-101. DOI: 10.1177/039463200702000111. View

Lin S, Wang Y, Lee M, Ku M, Sun H, Lu K . Clinical spectrum of acute rhinosinusitis among atopic and nonatopic children in Taiwan. Int J Pediatr Otorhinolaryngol. 2011; 76(1):70-5. DOI: 10.1016/j.ijporl.2011.10.002. View

Liao P, Sun H, Lu K, Lue K . Prevalence of childhood allergic diseases in central Taiwan over the past 15 years. Pediatr Neonatol. 2009; 50(1):18-25. DOI: 10.1016/S1875-9572(09)60025-5. View

Droma Y, Kunii O, Yangzom Y, Shan M, Pingzo L, Song P . Prevalence and severity of asthma and allergies in schoolchildren in Lhasa, Tibet. Clin Exp Allergy. 2007; 37(9):1326-33. DOI: 10.1111/j.1365-2222.2007.02781.x. View

Blair C, Nelson M, Thompson K, Boonlayangoor S, Haney L, Gabr U . Allergic inflammation enhances bacterial sinusitis in mice. J Allergy Clin Immunol. 2001; 108(3):424-9. DOI: 10.1067/mai.2001.117793. View

Wheatley L, Togias A . Clinical practice. Allergic rhinitis. N Engl J Med. 2015; 372(5):456-63. PMC: 4324099. DOI: 10.1056/NEJMcp1412282. View

Reid J . Complications of pediatric paranasal sinusitis. Pediatr Radiol. 2004; 34(12):933-42. DOI: 10.1007/s00247-004-1252-2. View

10.

Leo G, Incorvaia C, Cazzavillan A, Consonni D, Zuccotti G . Could seasonal allergy be a risk factor for acute rhinosinusitis in children?. J Laryngol Otol. 2018; 132(2):150-153. DOI: 10.1017/S0022215118000038. View

11.

Newman L, Platts-Mills T, Phillips C, Hazen K, Gross C . Chronic sinusitis. Relationship of computed tomographic findings to allergy, asthma, and eosinophilia. JAMA. 1994; 271(5):363-7. DOI: 10.1001/jama.271.5.363. View

12.

Huang W, Hung P . Methicillin-resistant Staphylococcus aureus infections in acute rhinosinusitis. Laryngoscope. 2006; 116(2):288-91. DOI: 10.1097/01.mlg.0000197316.36698.c4. View

13.

Marom T, Alvarez-Fernandez P, Jennings K, Patel J, McCormick D, Chonmaitree T . Acute bacterial sinusitis complicating viral upper respiratory tract infection in young children. Pediatr Infect Dis J. 2014; 33(8):803-8. PMC: 4165747. DOI: 10.1097/INF.0000000000000278. View

14.

Skoner D . Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. 2001; 108(1 Suppl):S2-8. DOI: 10.1067/mai.2001.115569. View

15.

Wald E, Applegate K, Bordley C, Darrow D, Glode M, Marcy S . Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years. Pediatrics. 2013; 132(1):e262-80. DOI: 10.1542/peds.2013-1071. View

16.

Ahmad N, Zacharek M . Allergic rhinitis and rhinosinusitis. Otolaryngol Clin North Am. 2008; 41(2):267-81, v. DOI: 10.1016/j.otc.2007.11.010. View

17.

Fang A, England J, Gausche-Hill M . Pediatric Acute Bacterial Sinusitis: Diagnostic and Treatment Dilemmas. Pediatr Emerg Care. 2015; 31(11):789-94. DOI: 10.1097/PEC.0000000000000599. View

18.

Kronemer K, McALISTER W . Sinusitis and its imaging in the pediatric population. Pediatr Radiol. 1998; 27(11):837-46. DOI: 10.1007/s002470050251. View

19.

Alho O, Karttunen T, Karttunen R, Tuokko H, Koskela M, Suramo I . Subjects with allergic rhinitis show signs of more severely impaired paranasal sinus functioning during viral colds than nonallergic subjects. Allergy. 2003; 58(8):767-71. DOI: 10.1034/j.1398-9995.2003.00252.x. View

20.

DeMuri G, Wald E . Acute bacterial sinusitis in children. Pediatr Rev. 2013; 34(10):429-37. DOI: 10.1542/pir.34-10-429. View