Addiction and Dopamine: Sex Differences and Insights from Studies of Smoking

Overview

Journal Curr Opin Behav Sci

Date 2019 Feb 13

PMID 30746429

Citations 5

Authors

Nicole Petersen

Edythe D London

Affiliations

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Abstract

Mesolimbic dopaminergic function influences addiction through effects on reinforcement learning, decision-making, and impulsivity. This review covers sex differences in dopaminergic neurochemistry, their hormonal and genetic determinants, and how differences in dopaminergic tone interact with sex and/or ovarian hormone status to affect cognitive functions. Findings from research on cigarette smoking reveal sex differences in striatal and midbrain dopamine D2-type receptor availability and striatal dopamine release that suggest mechanisms of nicotine dependence, and stronger subjective responses to nicotine and efficacy of nicotine replacement therapies in male smokers than in their female counterparts. Opportunities exist to extend such efforts in studies of how sex and hormone status influence other addictions.

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References

Kirby K, Petry N, Bickel W . Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. J Exp Psychol Gen. 1999; 128(1):78-87. DOI: 10.1037//0096-3445.128.1.78. View

Phillips T, Brown K, Burkhart-Kasch S, Wenger C, Kelly M, Rubinstein M . Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nat Neurosci. 1999; 1(7):610-5. DOI: 10.1038/2843. View

Grant S, Contoreggi C, London E . Drug abusers show impaired performance in a laboratory test of decision making. Neuropsychologia. 2000; 38(8):1180-7. DOI: 10.1016/s0028-3932(99)00158-x. View

Kaasinen V, Nagren K, Hietala J, Farde L, Rinne J . Sex differences in extrastriatal dopamine d(2)-like receptors in the human brain. Am J Psychiatry. 2001; 158(2):308-11. DOI: 10.1176/appi.ajp.158.2.308. View

Bickel W, Marsch L . Toward a behavioral economic understanding of drug dependence: delay discounting processes. Addiction. 2001; 96(1):73-86. DOI: 10.1046/j.1360-0443.2001.961736.x. View

Perkins K, Gerlach D, VENDER J, GROBE J, Meeker J, Hutchison S . Sex differences in the subjective and reinforcing effects of visual and olfactory cigarette smoke stimuli. Nicotine Tob Res. 2001; 3(2):141-50. DOI: 10.1080/14622200110043059. View

Sofuoglu M, Babb D, Hatsukami D . Progesterone treatment during the early follicular phase of the menstrual cycle: effects on smoking behavior in women. Pharmacol Biochem Behav. 2001; 69(1-2):299-304. DOI: 10.1016/s0091-3057(01)00527-5. View

Staley J, Krishnan-Sarin S, Zoghbi S, Tamagnan G, Fujita M, Seibyl J . Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse. 2001; 41(4):275-84. DOI: 10.1002/syn.1084. View

Delfino R, Jamner L, Whalen C . Temporal analysis of the relationship of smoking behavior and urges to mood states in men versus women. Nicotine Tob Res. 2001; 3(3):235-48. DOI: 10.1080/14622200110050466. View

10.

Thanos P, Volkow N, Freimuth P, Umegaki H, Ikari H, Roth G . Overexpression of dopamine D2 receptors reduces alcohol self-administration. J Neurochem. 2001; 78(5):1094-103. DOI: 10.1046/j.1471-4159.2001.00492.x. View

11.

Laakso A, Vilkman H, Bergman J, Haaparanta M, Solin O, Syvalahti E . Sex differences in striatal presynaptic dopamine synthesis capacity in healthy subjects. Biol Psychiatry. 2002; 52(7):759-63. DOI: 10.1016/s0006-3223(02)01369-0. View

12.

Dani J . Roles of dopamine signaling in nicotine addiction. Mol Psychiatry. 2003; 8(3):255-6. DOI: 10.1038/sj.mp.4001284. View

13.

Volkow N, Fowler J, Wang G . The addicted human brain: insights from imaging studies. J Clin Invest. 2003; 111(10):1444-51. PMC: 155054. DOI: 10.1172/JCI18533. View

14.

Volkow N, Fowler J, Wang G, Swanson J . Dopamine in drug abuse and addiction: results from imaging studies and treatment implications. Mol Psychiatry. 2004; 9(6):557-69. DOI: 10.1038/sj.mp.4001507. View

15.

Zhang H, Sulzer D . Frequency-dependent modulation of dopamine release by nicotine. Nat Neurosci. 2004; 7(6):581-2. DOI: 10.1038/nn1243. View

16.

Hernandez-Avila C, Rounsaville B, Kranzler H . Opioid-, cannabis- and alcohol-dependent women show more rapid progression to substance abuse treatment. Drug Alcohol Depend. 2004; 74(3):265-72. DOI: 10.1016/j.drugalcdep.2004.02.001. View

17.

Cepeda-Benito A, Reynoso J, Erath S . Meta-analysis of the efficacy of nicotine replacement therapy for smoking cessation: differences between men and women. J Consult Clin Psychol. 2004; 72(4):712-22. DOI: 10.1037/0022-006X.72.4.712. View

18.

Chen J, Lipska B, Halim N, Ma Q, Matsumoto M, Melhem S . Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet. 2004; 75(5):807-21. PMC: 1182110. DOI: 10.1086/425589. View

19.

Milsted A, Serova L, Sabban E, Dunphy G, Turner M, Ely D . Regulation of tyrosine hydroxylase gene transcription by Sry. Neurosci Lett. 2004; 369(3):203-7. DOI: 10.1016/j.neulet.2004.07.052. View

20.

Nolen-Hoeksema S . Gender differences in risk factors and consequences for alcohol use and problems. Clin Psychol Rev. 2004; 24(8):981-1010. DOI: 10.1016/j.cpr.2004.08.003. View