Geographic Clustering of Polygenic Scores at Different Stages of the Life Course

Overview

Journal RSF

Date 2019 Feb 12

PMID 30740524

Citations 8

Authors

Benjamin W Domingue

David H Rehkopf

Dalton Conley

Jason D Boardman

Affiliations

Soon will be listed here.

Abstract

We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent's state of birth with corresponding phenotypes. The polygenic scores for height and smoking show the most state-level clustering (2 to 4 percent) with relatively little clustering observed for the other scores. However, even the small amounts of observed clustering are potentially meaningful. The state-mean polygenic score for educational attainment is strongly associated with an individual's educational attainment net of that person's polygenic score. The ecological clustering of polygenic scores may denote a new environmental factor in gene-environment research. We conclude by discussing possible mechanisms that underlie this association and the implications of our findings for social and genetic research.

Citing Articles

Rare genetic variants explain missing heritability in smoking.

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Evaluating the Continued Integration of Genetics into Medical Sociology.

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Becker J, Burik C, Goldman G, Wang N, Jayashankar H, Bennett M Nat Hum Behav. 2021; 5(12):1744-1758.

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Genetic correlates of social stratification in Great Britain.

Abdellaoui A, Hugh-Jones D, Yengo L, Kemper K, Nivard M, Veul L Nat Hum Behav. 2019; 3(12):1332-1342.

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