Gene Polymorphism and Their Risk Association With Type 2 Diabetes Mellitus

Overview

Journal Open Access Maced J Med Sci

Specialty General Medicine

Date 2019 Feb 12

PMID 30740156

Citations 4

Authors

Hakim Bahlok Jebur

Mirza Masroor

Hafiz Ahmad

Naushad Ahmad Khan

Juheb Akther

Dipu Bharali

Vijay Kumar Singh

Amit Verma

Shahbaz Khan

Vasiuddin Khan

Rameez Hasan

Deepti Bhatt

Yamini Goyal

Kapil Dev

Affiliations

Soon will be listed here.

Abstract

Background: C-reactive protein (CRP) is an inflammatory marker associated with T2DM, obesity, insulin resistance, and cardiovascular disease.

Aim: The present study evaluates the association of CRP +1059 G/C polymorphism of the gene in 100 T2D cases and 100 healthy controls.

Methods: Present study was done by allele specific PCR method to study the gene polymorphism in study subjects.

Results: Study found that (+1059 G/C) genotype distribution among case and controls was found to be significant (p=0.001), Higher C allele frequency (0.16) was observed compared to controls (0.04). +1059 GC and CC had 2.72 (1.12-6.61), 20.56 (1.16-362.1) risk for T2D. It has been observed, HTN, Obesity, Smoking and alcoholism was found to be associated with increased risk of T2D, and a significant difference was observed in biochemical parameters.

Conclusion: Study concluded that gene polymorphism was found to be associated with risk of Type 2 Diabetes and risk was linked with heterozygosity and mutant homozygosity. Hypertension, Obesity, Smoking and alcoholism increases the risk of occurrence of Type 2 Diabetes.

Citing Articles

Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome.

Lopez-Roblero A, Serrano-Guzman E, Guerrero-Baez R, Delgado-Enciso I, Gomez-Manzo S, Aguilar-Fuentes J Biomed Rep. 2024; 21(5):150.

PMID: 39247423 PMC: 11375626. DOI: 10.3892/br.2024.1838.

Haplotype analysis on association between C-reactive protein gene and susceptibility to type 2 diabetes mellitus in Chinese Han population : CRP gene and type 2 diabetes mellitus.

Luo W, Qiang D, Zhu W, Kong X, Xu W Acta Diabetol. 2024; 61(11):1423-1432.

PMID: 38833006 DOI: 10.1007/s00592-024-02309-x.

High sensitivity C-reactive protein and prediabetes progression and regression in middle-aged and older adults: A prospective cohort study.

Cheng Z, Wang Y, Jiang X, Ren W, Lei S, Deng F J Diabetes Investig. 2023; 15(1):78-86.

PMID: 37803908 PMC: 10759715. DOI: 10.1111/jdi.14090.

Association Between CDKAL1, HHEX, CDKN2A/2B and IGF2BP2 Gene Polymorphisms and Susceptibility to Type 2 Diabetes in Uttarakhand, India.

Verma A, Goyal Y, Bhatt D, Ali Beg M, Dev K, Alsahli M Diabetes Metab Syndr Obes. 2021; 14:23-36.

PMID: 33442279 PMC: 7797276. DOI: 10.2147/DMSO.S284998.

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