Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2019 Feb 10

PMID 30736430

Citations 5

Authors

Imke Rudnik-Jansen

Nina Woike

Suzanne de Jong

Sabine Versteeg

Marja Kik

Pieter Emans

George Mihov

Jens Thies

Niels Eijkelkamp

Marianna Tryfonidou

Laura Creemers

Affiliations

Soon will be listed here.

Abstract

Episodes of inflammation and pain are predominant features of arthritic joint diseases. Drug delivery systems (DDS) could reduce inflammation and pain long-term without chances of infection upon multiple injections. To allow for long-term evaluation of DDS, we modified a previously published acute arthritis model by extending follow-up periods between flare-ups. Unilateral synovial inflammation of the knee was induced by intra-articular injection of streptococcal cell wall peptidoglycan polysaccharide (PGPS), and flare-ups were induced by intravenous PGPS injections every 4 weeks for a total duration of 84 days. In PGPS-reactivated animals, joint swelling, pain behavior, post mortem synovitis, and osteophyte formation were notable features. Hepatitis, splenitis and inflammation of non-primed joints were observed as systemic side effects. To test the applicability of the modified arthritis model for long-term testing of DDS, the duration of anti-inflammatory and analgesic effects of a corticosteroid released from two different polymer-based platforms was evaluated. The current modified arthritis model has good applicability for testing of DDS for a prolonged period of time. Furthermore, the novel autoregulatory polyesteramide (PEA) microsphere platform releasing triamcinolone acetonide (TAA) was benchmarked against poly lactic-co-glycolic acid (PLGA) and reduced joint swelling and pain behavior more potently compared to TAA-loaded PLGA microspheres.

Citing Articles

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Intra-Articular Slow-Release Triamcinolone Acetonide from Polyesteramide Microspheres as a Treatment for Osteoarthritis.

Tellegen A, Beukers M, Rudnik-Jansen I, van Klaveren N, How K, Woike N Pharmaceutics. 2021; 13(3).

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Association between Oncostatin M Expression and Inflammatory Phenotype in Experimental Arthritis Models and Osteoarthritis Patients.

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Design and In Vivo Pharmacokinetic Evaluation of Triamcinolone Acetonide Microcrystals-Loaded PLGA Microsphere for Increased Drug Retention in Knees after Intra-Articular Injection.

Ho M, Jeong H, Im S, Kim H, Lee J, Park J Pharmaceutics. 2019; 11(8).

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Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing.

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PMID: 31378925 PMC: 6811746. DOI: 10.1111/bph.14817.

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