Design, Synthesis, and Herbicidal Activity Evaluation of Novel Aryl-Naphthyl Methanone Derivatives

Overview

Journal Front Chem

Specialty Chemistry

Date 2019 Feb 7

PMID 30723715

Citations 8

Authors

Ying Fu

Kui Wang

Peng Wang

Jing-Xin Kang

Shuang Gao

Li-Xia Zhao

Fei Ye

Affiliations

Soon will be listed here.

Abstract

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is one of the most vital targets for herbicides discovery. In search for HPPD inhibitors with novel scaffolds, a series of aryl-naphthyl methanone derivatives have been designed and synthesized through alkylation and Friedel-Crafts acylation reactions. The bioassay indicated some of these compounds displayed preferable herbicidal activity at the rate of 0.75 mmol/m by post-emergence application, in which compound displayed the best herbicidal activity. The molecular docking showed that compound could bind well to the active site of the HPPD. This study shows that aryl-naphthyl methanone derivatives could be a potential lead structure for further development of novel herbicides.

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