» Articles » PMID: 3072140

Clinical Pharmacokinetics of Doxycycline and Minocycline

Overview
Specialty Pharmacology
Date 1988 Dec 1
PMID 3072140
Citations 114
Authors
Affiliations
Soon will be listed here.
Abstract

Doxycycline and minocycline are second-generation tetracyclines. They are readily absorbed, distributed throughout the organism as a function of their lipophilicity and eliminated in both the urine and the faeces. The influence of age, renal disease, malnutrition and hyperlipidaemia is reviewed, together with the main pharmacokinetic interactions.

Citing Articles

Increased usage of doxycycline for young children with Lyme disease.

Thompson A, Neville D, Chapman L, Balamuth F, Ladell M, Kharbanda A Front Antibiot. 2025; 3():1388039.

PMID: 39816267 PMC: 11732018. DOI: 10.3389/frabi.2024.1388039.


Generalized type II minocycline-induced pigmentation: A case report.

Zhao W, Fu H, Xu T, Shan S SAGE Open Med Case Rep. 2024; 12:2050313X241297214.

PMID: 39564131 PMC: 11574909. DOI: 10.1177/2050313X241297214.


Doxycycline Post-Exposure Prophylaxis for Bacterial Sexually Transmitted Infections: The Current Landscape and Future Directions.

Allan-Blitz L, Mayer K Curr HIV/AIDS Rep. 2024; 22(1):1.

PMID: 39476167 DOI: 10.1007/s11904-024-00709-w.


Severe Discoloration of the Alveolar Bone Secondary to Long-Term Minocycline Therapy: A Case Report.

Friedl R, Jackson T, Dinh T, Yoon T Cureus. 2024; 16(7):e64672.

PMID: 39149683 PMC: 11326716. DOI: 10.7759/cureus.64672.


Comparative Evaluation of Antimicrobial Efficacy of Triple Antibiotic Paste Herbal Combination and Camphorated Monochlorophenol as Intracanal Medicaments against in Deciduous Molars: An Study.

Tawde M, Lakade L, Patil S, Kamble A, Patel A, Jajoo S Int J Clin Pediatr Dent. 2024; 17(3):243-254.

PMID: 39144514 PMC: 11320782. DOI: 10.5005/jp-journals-10005-2768.


References
1.
Jonas M, Cunha B . Minocycline. Ther Drug Monit. 1982; 4(2):137-45. View

2.
Raghuram T, Krishnaswamy K . Pharmacokinetics and plasma steady state levels of doxycycline in undernutrition. Br J Clin Pharmacol. 1982; 14(6):785-9. PMC: 1427538. DOI: 10.1111/j.1365-2125.1982.tb02037.x. View

3.
Smith C, Woods C, Woods M . Absorption of minocycline. J Antimicrob Chemother. 1984; 13(1):93. DOI: 10.1093/jac/13.1.93. View

4.
WHELTON A, Blanco L, Carter G, Craig T, Bryant H, Herbst D . Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract. Obstet Gynecol. 1980; 55(1):28-32. View

5.
ZECH P . [Use of doxycycline in human renal failure]. Nouv Presse Med. 1980; 9(21 Suppl):82-3. View