Pressurized Intraperitoneal Aerosol Chemotherapy and Its Effect on Gastric-cancer-derived Peritoneal Metastases: an Overview

Overview

Journal Clin Exp Metastasis

Specialty Oncology

Date 2019 Feb 5

PMID 30715654

Citations 11

Authors

Miguel Alberto

Andreas Brandl

Pankaj Kumar Garg

Safak Gul-Klein

Mathias Dahlmann

Ulrike Stein

Beate Rau

Affiliations

Soon will be listed here.

Abstract

This manuscript aspires to portray a review of the current literature focusing on manifest peritoneal metastasis (PM) derived from gastric cancer and its treatment options. Despite the development of chemotherapy and multimodal treatment options during the last decades, mortality remains high worldwide. After refreshing important epidemiological considerations, the molecular mechanisms currently accepted through which PM occurs are revised. Palliative chemotherapy is the only recommended treatment option for patients with PM of gastric cancer according to the National Comprehensive Cancer Network guidelines, although cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy demonstrated promising results in selected patients with regional PM and localized intraabdominal tumor spread. A novel treatment named pressurized intraperitoneal aerosol chemotherapy may have a promising future in improving overall survival with an acceptable postoperative complication rate and stabilizing quality of life during treatment. Additionally, the procedure has been proved to be safe for the patient and medical personnel and a feasible, repeatable method to deter metastatic proliferation. This overview comprehensively addresses this novel and promising treatment in the context of a scientifically and clinically challenging disease.

Citing Articles

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in the Treatment of Gastric Cancer: Feasibility, Efficacy and Safety-A Systematic Review and Meta-Analysis.

Ramalho-Vasconcelos F, Gomes R, Bouca-Machado R, Aral M, Nogueiro J, Bouca-Machado T J Clin Med. 2024; 13(11).

PMID: 38893031 PMC: 11173180. DOI: 10.3390/jcm13113320.

RSPO3 induced by Helicobacter pylori extracts promotes gastric cancer stem cell properties through the GNG7/β-catenin signaling pathway.

Rao X, Zhang Z, Pu Y, Han G, Gong H, Hu H Cancer Med. 2024; 13(7):e7092.

PMID: 38581123 PMC: 10997846. DOI: 10.1002/cam4.7092.

Surgical Options for Peritoneal Surface Metastases from Digestive Malignancies-A Comprehensive Review.

Eftimie M, Potlog G, Alexandrescu S Medicina (Kaunas). 2023; 59(2).

PMID: 36837456 PMC: 9960111. DOI: 10.3390/medicina59020255.

Editorial: Multimodal management of advanced gastric cancer.

Garg P, Brandl A, Marano L Front Oncol. 2023; 12:1113856.

PMID: 36644635 PMC: 9836001. DOI: 10.3389/fonc.2022.1113856.

Integration of Genomic Biology Into Therapeutic Strategies of Gastric Cancer Peritoneal Metastasis.

Gwee Y, Chia D, So J, Ceelen W, Yong W, Tan P J Clin Oncol. 2022; 40(24):2830.

PMID: 35649219 PMC: 9390822. DOI: 10.1200/JCO.21.02745.

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