6.
Godoy P, Hewitt N, Albrecht U, Andersen M, Ansari N, Bhattacharya S
. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol. 2013; 87(8):1315-530.
PMC: 3753504.
DOI: 10.1007/s00204-013-1078-5.
View
7.
Waldmann T, Rempel E, Balmer N, Konig A, Kolde R, Gaspar J
. Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014; 27(3):408-20.
PMC: 3958134.
DOI: 10.1021/tx400402j.
View
8.
Weng M, Natarajan K, Scholz D, Ivanova V, Sachinidis A, Hengstler J
. Lineage-specific regulation of epigenetic modifier genes in human liver and brain. PLoS One. 2014; 9(7):e102035.
PMC: 4108363.
DOI: 10.1371/journal.pone.0102035.
View
9.
Meganathan K, Jagtap S, Srinivasan S, Wagh V, Hescheler J, Hengstler J
. Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells. Cell Death Dis. 2015; 6:e1756.
PMC: 4669700.
DOI: 10.1038/cddis.2015.121.
View
10.
Rempel E, Hoelting L, Waldmann T, Balmer N, Schildknecht S, Grinberg M
. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015; 89(9):1599-618.
PMC: 4551554.
DOI: 10.1007/s00204-015-1573-y.
View
11.
Sampaio S, Branco A, Wojtala A, Vega-Naredo I, Wieckowski M, Oliveira P
. p66Shc signaling is involved in stress responses elicited by anthracycline treatment of rat cardiomyoblasts. Arch Toxicol. 2015; 90(7):1669-84.
DOI: 10.1007/s00204-015-1583-9.
View
12.
Chaudhari U, Nemade H, Wagh V, Gaspar J, Ellis J, Srinivasan S
. Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol. 2015; 90(11):2763-2777.
PMC: 5065579.
DOI: 10.1007/s00204-015-1623-5.
View
13.
Pallocca G, Grinberg M, Henry M, Frickey T, Hengstler J, Waldmann T
. Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2015; 90(1):159-80.
PMC: 4710658.
DOI: 10.1007/s00204-015-1658-7.
View
14.
Chaudhari U, Nemade H, Gaspar J, Hescheler J, Hengstler J, Sachinidis A
. MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2016; 90(12):3087-3098.
PMC: 5104806.
DOI: 10.1007/s00204-016-1668-0.
View
15.
Shinde V, Hoelting L, Srinivasan S, Meisig J, Meganathan K, Jagtap S
. Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox and STOP-Tox tests. Arch Toxicol. 2016; 91(2):839-864.
PMC: 5306084.
DOI: 10.1007/s00204-016-1741-8.
View
16.
Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C
. Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue. Arch Toxicol. 2016; 90(10):2513-29.
PMC: 5043005.
DOI: 10.1007/s00204-016-1761-4.
View
17.
Leist M, Ghallab A, Graepel R, Marchan R, Hassan R, Bennekou S
. Adverse outcome pathways: opportunities, limitations and open questions. Arch Toxicol. 2017; 91(11):3477-3505.
DOI: 10.1007/s00204-017-2045-3.
View
18.
Godoy P, Schmidt-Heck W, Hellwig B, Nell P, Feuerborn D, Rahnenfuhrer J
. Assessment of stem cell differentiation based on genome-wide expression profiles. Philos Trans R Soc Lond B Biol Sci. 2018; 373(1750).
PMC: 5974444.
DOI: 10.1098/rstb.2017.0221.
View
19.
Karhu S, Valimaki M, Jumppanen M, Kinnunen S, Pohjolainen L, Leigh R
. Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds. Arch Toxicol. 2018; 92(9):2897-2911.
PMC: 6132687.
DOI: 10.1007/s00204-018-2257-1.
View