Does TheFMR1 Gene Affect IVF Success?

Overview

Journal Reprod Biomed Online

Publisher Elsevier

Specialty Reproductive Medicine

Date 2019 Feb 4

PMID 30711457

Citations 6

Authors

Lisa M Pastore

Mindy S Christianson

Bailey McGuinness

Kamaria Cayton Vaught

Jacqueline Y Maher

William G Kearns

Affiliations

Soon will be listed here.

Abstract

FMR1 CGG trinucleotide repeat expansions are associated with Fragile X syndrome (full mutations) and primary ovarian insufficiency (premutation range); the effect of FMR1 on the success of fertility treatment is unclear. The effect of FMR1 CGG repeat lengths on IVF outcomes after ovarian stimulation was reviewed. PubMed was searched for studies on IVF-related outcomes reported by FMR1 trinucleotide repeat length published between 2002 and December 2017. For women with CGG repeats in the normal (<45 CGG), intermediate range (45-54 CGG), or both, research supports a minimal effect on IVF outcomes, including pregnancy rates; although one study reported lower oocyte yields after IVF stimulation in women with lower CGG repeat lengths and normal ovarian reserve. Meta-analysis revealed no association within subcategories of normal repeat length (<45 CGG) and IVF pregnancy rates (summary OR 1.0, 95% CI 0.87 to 1.15). Premutation carriers (CGG 55-200) may have reduced success with IVF treatment (lower oocyte yield) than women with a normal CGG repeat length or a full mutation, although findings are inconsistent. Direct implications of the repeat length on inheritance and the risk of Fragile X syndrome have been observed. Patients may require clinical and psychological counselling, and further preimplantation genetic testing options should be considered. Thus, there are clinical and psychological counseling implications for patients and potential further patient decisions regarding preimplantation genetic testing options.

Citing Articles

Prevalence of the Gene Premutation in Young Women with a Diminished Ovarian Reserve Included in an IVF Program: Implications for Clinical Practice.

Agusti I, Mendez M, Borras A, Goday A, Guimera M, Peralta S Genes (Basel). 2024; 15(8).

PMID: 39202368 PMC: 11353426. DOI: 10.3390/genes15081008.

Fragile X Syndrome Secondary to in Vitro Fertilization With a Family Egg Donor: A Case Report and Review of the Literature.

Gonzalez-Teshima L, Payan-Gomez C, Saldarriaga W J Family Reprod Health. 2021; 15(2):130-135.

PMID: 34721603 PMC: 8520665. DOI: 10.18502/jfrh.v15i2.6455.

Association between mutations in the FMR1 gene and ovarian dysfunction in Brazilian patients.

Ramos C, Ocampos M, Barbato I, Niehues V, da Graca Bicalho M, Nisihara R JBRA Assist Reprod. 2021; 26(2):237-240.

PMID: 34542254 PMC: 9118958. DOI: 10.5935/1518-0557.20210063.

The molecular mechanisms that underlie fragile X-associated premature ovarian insufficiency: is it RNA or protein based?.

Rosario R, Anderson R Mol Hum Reprod. 2020; 26(10):727-737.

PMID: 32777047 PMC: 7566375. DOI: 10.1093/molehr/gaaa057.

Does the presence of AGG interruptions within the CGG repeat tract have a protective effect on the fertility phenotype of female FMR1 premutation carriers?.

Friedman-Gohas M, Kirshenbaum M, Michaeli A, Domniz N, Elizur S, Raanani H J Assist Reprod Genet. 2020; 37(4):849-854.

PMID: 32096109 PMC: 7183013. DOI: 10.1007/s10815-020-01701-0.

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