» Articles » PMID: 30709884

Propranolol As an Effective Therapy for Infantile Haemangioma of the Urinary Bladder

Overview
Journal BMJ Case Rep
Specialty General Medicine
Date 2019 Feb 3
PMID 30709884
Citations 1
Authors
Affiliations
Soon will be listed here.
Abstract

Infantile haemangiomas are one of the most common tumours in infancy, but typically present as cutaneous lesions; haemangiomas of the urinary bladder are incredibly rare. Although benign, these can sometimes ulcerate and bleed, causing haematuria in the case of bladder lesions. Propranolol is a well-documented medical therapy for cutaneous lesions, but surgical treatment dominates the literature on bladder haemangiomas. We present the case of a child with infantile haemangiomas of the urinary bladder, as well as internal and cutaneous lesions, treated with propranolol. At 6-week follow-up cystoscopy and MRI, there was a significant improvement in both bladder and internal lesions, respectively. Follow-up with dermatology 9 months after initiation of propranolol demonstrated excellent regression of the cutaneous lesions with a marked decrease in both size and prominence. This case demonstrates the potential role of propranolol in the treatment of bladder haemangiomas in lieu of more invasive surgical techniques.

Citing Articles

Infantile Sacral Region Hemangioma and Combination Treatment with Propranolol and Topical Timolol: Case Review and Reference Review.

Kardasevic M, Dinarevic S Med Arch. 2021; 75(2):158-161.

PMID: 34219878 PMC: 8228564. DOI: 10.5455/medarh.2021.75.158-161.

References
1.
Fernandes E, Manivel J, Reinberg Y . Hematuria in a newborn infant caused by bladder hemangioma. Urology. 1996; 47(3):412-5. DOI: 10.1016/s0090-4295(99)80463-4. View

2.
Girard C, Bigorre M, Guillot B, Bessis D . PELVIS Syndrome. Arch Dermatol. 2006; 142(7):884-8. DOI: 10.1001/archderm.142.7.884. View

3.
Reinhard M, Schuchardt F, Meckel S, Heinz J, Felbor U, Sure U . Propranolol stops progressive multiple cerebral cavernoma in an adult patient. J Neurol Sci. 2016; 367:15-7. DOI: 10.1016/j.jns.2016.04.053. View

4.
Kilcline C, Frieden I . Infantile hemangiomas: how common are they? A systematic review of the medical literature. Pediatr Dermatol. 2008; 25(2):168-73. DOI: 10.1111/j.1525-1470.2008.00626.x. View

5.
Jibhkate S, Sanklecha V, Valand A . Urinary bladder hemangioma -a rare urinary bladder tumor in a child. APSP J Case Rep. 2015; 6(1):6. PMC: 4288837. View