Biological Function and Molecular Mechanism of PiRNA in Cancer

Overview

Journal Pract Lab Med

Specialty Biochemistry

Date 2019 Feb 2

PMID 30705933

Citations 33

Authors

Ghanbar Mahmoodi Chalbatani

Hassan Dana

Feridon Memari

Elahe Gharagozlou

Shirin Ashjaei

Peyman Kheirandish

Vahid Marmari

Habibollah Mahmoudzadeh

Farnaz Mozayani

Ali Reza Maleki

Ehsan Sadeghian

Elham Zainali Nia

Seyed Rohollah Miri

Neda Zainali Nia

Omid Rezaeian

Anahita Eskandary

Narges Razavi

Mohammad Shirkhoda

Fatemeh Nouri Rouzbahani

Affiliations

Soon will be listed here.

Abstract

Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds of cancers including gastric cancer, bladder cancer, breast cancer, colorectal cancer and Lung cancer and may probably serve as a novel therapeutic target and biomarker for cancer treatment. The present review summarized current advances in our knowledge of the roles of piRNAs in cancer.

Citing Articles

piR-823 tale as emerging cancer-hallmark molecular marker in different cancer types: a step-toward ncRNA-precision.

Shaker F, Sanad E, Elghazaly H, Hsia S, Hamdy N Naunyn Schmiedebergs Arch Pharmacol. 2024; 398(1):47-68.

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PIWI-interacting RNAs (PiRNAs) as emerging biomarkers and therapeutic targets in biliary tract cancers: A comprehensive review.

Ahmadi Asouri S, Aghadavood E, Mirzaei H, Abaspour A, Shahaboddin M Heliyon. 2024; 10(13):e33767.

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ncRNAs: an unexplored cellular defense mechanism in leprosy.

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RNA-Based Liquid Biopsy in Head and Neck Cancer.

Kabzinski J, Kucharska-Lusina A, Majsterek I Cells. 2023; 12(14).

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Serum Exosome-Derived piRNAs Could Be Promising Biomarkers for HCC Diagnosis.

Rui T, Wang K, Xiang A, Guo J, Tang N, Jin X Int J Nanomedicine. 2023; 18:1989-2001.

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References

Carmell M, Xuan Z, Zhang M, Hannon G . The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 2002; 16(21):2733-42. DOI: 10.1101/gad.1026102. View

Baylin S . DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol. 2005; 2 Suppl 1:S4-11. DOI: 10.1038/ncponc0354. View

Aravin A, Gaidatzis D, Pfeffer S, Lagos-Quintana M, Landgraf P, Iovino N . A novel class of small RNAs bind to MILI protein in mouse testes. Nature. 2006; 442(7099):203-7. DOI: 10.1038/nature04916. View

Vagin V, Sigova A, Li C, Seitz H, Gvozdev V, Zamore P . A distinct small RNA pathway silences selfish genetic elements in the germline. Science. 2006; 313(5785):320-4. DOI: 10.1126/science.1129333. View

Wilson A, Power B, Molloy P . DNA hypomethylation and human diseases. Biochim Biophys Acta. 2006; 1775(1):138-62. DOI: 10.1016/j.bbcan.2006.08.007. View

Brennecke J, Aravin A, Stark A, Dus M, Kellis M, Sachidanandam R . Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell. 2007; 128(6):1089-103. DOI: 10.1016/j.cell.2007.01.043. View

Houwing S, Kamminga L, Berezikov E, Cronembold D, Girard A, van den Elst H . A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell. 2007; 129(1):69-82. DOI: 10.1016/j.cell.2007.03.026. View

Yin H, Lin H . An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. Nature. 2007; 450(7167):304-8. DOI: 10.1038/nature06263. View

Xu M, You Y, Hunsicker P, Hori T, Small C, Griswold M . Mice deficient for a small cluster of Piwi-interacting RNAs implicate Piwi-interacting RNAs in transposon control. Biol Reprod. 2008; 79(1):51-7. DOI: 10.1095/biolreprod.108.068072. View

10.

Ghildiyal M, Zamore P . Small silencing RNAs: an expanding universe. Nat Rev Genet. 2009; 10(2):94-108. PMC: 2724769. DOI: 10.1038/nrg2504. View

11.

Siomi H, Siomi M . On the road to reading the RNA-interference code. Nature. 2009; 457(7228):396-404. DOI: 10.1038/nature07754. View

12.

Moazed D . Small RNAs in transcriptional gene silencing and genome defence. Nature. 2009; 457(7228):413-20. PMC: 3246369. DOI: 10.1038/nature07756. View

13.

Ploeg M, Aben K, Kiemeney L . The present and future burden of urinary bladder cancer in the world. World J Urol. 2009; 27(3):289-93. PMC: 2694323. DOI: 10.1007/s00345-009-0383-3. View

14.

McClatchey A, Fehon R . Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex. Trends Cell Biol. 2009; 19(5):198-206. PMC: 2796113. DOI: 10.1016/j.tcb.2009.02.006. View

15.

van Wolfswinkel J, Ketting R . The role of small non-coding RNAs in genome stability and chromatin organization. J Cell Sci. 2010; 123(Pt 11):1825-39. DOI: 10.1242/jcs.061713. View

16.

Siomi M, Sato K, Pezic D, Aravin A . PIWI-interacting small RNAs: the vanguard of genome defence. Nat Rev Mol Cell Biol. 2011; 12(4):246-58. DOI: 10.1038/nrm3089. View

17.

Watanabe T, Tomizawa S, Mitsuya K, Totoki Y, Yamamoto Y, Kuramochi-Miyagawa S . Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science. 2011; 332(6031):848-52. PMC: 3368507. DOI: 10.1126/science.1203919. View

18.

Neisch A, Fehon R . Ezrin, Radixin and Moesin: key regulators of membrane-cortex interactions and signaling. Curr Opin Cell Biol. 2011; 23(4):377-82. PMC: 3148288. DOI: 10.1016/j.ceb.2011.04.011. View

19.

Cheng J, Guo J, Xiao B, Miao Y, Jiang Z, Zhou H . piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells. Clin Chim Acta. 2011; 412(17-18):1621-5. DOI: 10.1016/j.cca.2011.05.015. View

20.

Cui L, Lou Y, Zhang X, Zhou H, Deng H, Song H . Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers. Clin Biochem. 2011; 44(13):1050-1057. DOI: 10.1016/j.clinbiochem.2011.06.004. View