Applications of Stem Cells and Bioprinting for Potential Treatment of Diabetes

Overview

Journal World J Stem Cells

Publisher Baishideng Publishing Group

Date 2019 Feb 2

PMID 30705712

Citations 12

Authors

Shweta Anil Kumar

Monica Delgado

Victor E Mendez

Binata Joddar

Affiliations

Soon will be listed here.

Abstract

Currently, there does not exist a strategy that can reduce diabetes and scientists are working towards a cure and innovative approaches by employing stem cell-based therapies. On the other hand, bioprinting technology is a novel therapeutic approach that aims to replace the diseased or lost β-cells, insulin-secreting cells in the pancreas, which can potentially regenerate damaged organs such as the pancreas. Stem cells have the ability to differentiate into various cell lines including insulin-producing cells. However, there are still barriers that hamper the successful differentiation of stem cells into β-cells. In this review, we focus on the potential applications of stem cell research and bioprinting that may be targeted towards replacing the β-cells in the pancreas and may offer approaches towards treatment of diabetes. This review emphasizes on the applicability of employing both stem cells and other cells in 3D bioprinting to generate substitutes for diseased β-cells and recover lost pancreatic functions. The article then proceeds to discuss the overall research done in the field of stem cell-based bioprinting and provides future directions for improving the same for potential applications in diabetic research.

Citing Articles

Advanced therapy to cure diabetes: mission impossible is now possible?.

Rohban R, Martins C, Esni F Front Cell Dev Biol. 2024; 12:1484859.

PMID: 39629270 PMC: 11611888. DOI: 10.3389/fcell.2024.1484859.

New Frontiers in Three-Dimensional Culture Platforms to Improve Diabetes Research.

Mohandas S, Gayatri V, Kumaran K, Gopinath V, Paulmurugan R, Ramkumar K Pharmaceutics. 2023; 15(3).

PMID: 36986591 PMC: 10056755. DOI: 10.3390/pharmaceutics15030725.

Demonstration of doxorubicin's cardiotoxicity and screening using a 3D bioprinted spheroidal droplet-based system.

El Khoury R, Ramirez S, Loyola C, Joddar B RSC Adv. 2023; 13(12):8338-8351.

PMID: 36922946 PMC: 10010162. DOI: 10.1039/d3ra00421j.

3D bioprinting and its innovative approach for biomedical applications.

Tripathi S, Mandal S, Bauri S, Maiti P MedComm (2020). 2022; 4(1):e194.

PMID: 36582305 PMC: 9790048. DOI: 10.1002/mco2.194.

Bioprinting and its Use in Tumor-On-A-Chip Technology for Cancer Drug Screening: A Review.

Fang L, Liu Y, Qiu J, Wan W Int J Bioprint. 2022; 8(4):603.

PMID: 36404793 PMC: 9668576. DOI: 10.18063/ijb.v8i4.603.

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