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Periodontal, Metabolic, and Cardiovascular Disease: Exploring the Role of Inflammation and Mental Health

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Journal Pteridines
Date 2019 Feb 2
PMID 30705520
Citations 19
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Abstract

Previous evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.

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References
1.
Stashenko P, Fujiyoshi P, Obernesser M, Prostak L, Haffajee A, Socransky S . Levels of interleukin 1 beta in tissue from sites of active periodontal disease. J Clin Periodontol. 1991; 18(7):548-54. DOI: 10.1111/j.1600-051x.1991.tb00088.x. View

2.
Lu H, Raptis M, Black E, Stan M, Amar S, Graves D . Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue. Endocrinology. 2004; 145(11):4934-9. DOI: 10.1210/en.2004-0737. View

3.
Zheng P, Chen H, Shi S, Jepsen S, Eberhard J . Periodontal parameters and platelet-activating factor levels in serum and gingival crevicular fluid in a Chinese population. J Clin Periodontol. 2006; 33(11):797-802. DOI: 10.1111/j.1600-051X.2006.00987.x. View

4.
Dabelea D, Bell R, DAgostino Jr R, Imperatore G, Johansen J, Linder B . Incidence of diabetes in youth in the United States. JAMA. 2007; 297(24):2716-24. DOI: 10.1001/jama.297.24.2716. View

5.
Ahn Y, Shin M, Han D, Sukhbaatar M, Kim M, Shin H . Periodontitis is associated with the risk of subclinical atherosclerosis and peripheral arterial disease in Korean adults. Atherosclerosis. 2016; 251:311-318. DOI: 10.1016/j.atherosclerosis.2016.07.898. View