Integrated Seroprevalence-based Assessment of Wuchereria Bancrofti and Onchocerca Volvulus in Two Lymphatic Filariasis Evaluation Units of Mali with the SD Bioline Onchocerciasis/LF IgG4 Rapid Test

Overview

Journal PLoS Negl Trop Dis

Specialties Infectious Diseases
Tropical Medicine

Date 2019 Jan 31

PMID 30699120

Citations 8

Authors

Housseini Dolo

Yaya Ibrahim Coulibaly

Benoit Dembele

Boubacar Guindo

Siaka Yamoussa Coulibaly

Ilo Dicko

Salif Seriba Doumbia

Massitan Dembele

Mamadou Oumar Traore

Seydou Goita

Mamadou Dolo

Lamine Soumaoro

Michel Emmanuel Coulibaly

Abdallah Amadou Diallo

Dansine Diarra

Yaobi Zhang

Robert Colebunders

Thomas B Nutman

Affiliations

Soon will be listed here.

Abstract

Background: Mali has become increasingly interested in the evaluation of transmission of both Wuchereria bancrofti and Onchocerca volvulus as prevalences of both infections move toward their respective elimination targets. The SD Bioline Onchocerciasis/LF IgG4 Rapid Test was used in 2 evaluation units (EU) to assess its performance as an integrated surveillance tool for elimination of lymphatic filariasis (LF) and onchocerciasis.

Methodology/principal Findings: A cross sectional survey with SD Bioline Onchocerciasis/LF IgG4 Rapid Test was piggy-backed onto a transmission assessment survey (TAS) (using the immunochromatographic card test (ICT) Binax Filariasis Now test for filarial adult circulating antigen (CFA) detection) for LF in Mali among 6-7 year old children in 2016 as part of the TAS in two EUs namely Kadiolo-Kolondieba in the region of Sikasso and Bafoulabe -Kita-Oussoubidiagna-Yelimane in the region of Kayes. In the EU of Kadiolo- Kolondieba, of the 1,625 children tested, the overall prevalence of W. bancrofti CFA was 0.62% (10/1,625) [CI = 0.31-1.09]; while that of IgG4 to Wb123 was 0.19% (3/1,600) [CI = 0.04-0.50]. The number of positives tested with the two tests were statistically comparable (p = 0.09). In the EU of Bafoulabe-Kita-Oussoubidiagna-Yelimane, an overall prevalence of W. bancrofti CFA was 0% (0/1,700) and that of Wb123 IgG4 antibody was 0.06% (1/1,700), with no statistically significant difference between the two rates (p = 0.99). In the EU of Kadiolo- Kolondieba, the prevalence of Ov16-specific IgG4 was 0.19% (3/1,600) [CI = 0.04-0.50]. All 3 positives were in the previously O. volvulus-hyperendemic district of Kolondieba. In the EU of Bafoulabe-Kita-Oussoubidiagna-Yelimane, an overall prevalence of Ov16-specific IgG4 was 0.18% (3/1,700) [CI = 0.04-0.47]. These 3 Ov16 IgG4 positives were from previously O.volvulus-mesoendemic district of Kita.

Conclusions/significance: The SD Bioline Onchocerciasis/LF IgG4 Rapid test appears to be a good tool for integrated exposure measures of LF and onchocerciasis in co-endemic areas.

Citing Articles

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Progress towards elimination of onchocerciasis transmission in Mali: A "pre-stop MDA" survey in 18 transmission zones.

Dolo H, Coulibaly M, Sow M, Coulibaly Y, Doumbia M, Sangare M PLoS Negl Trop Dis. 2023; 17(11):e0011632.

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Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making.

Nana-Djeunga H, Sicard C, Mogoung-Wafo A, Chesnais C, Deleglise H, Touka-Nounkeu R Am J Trop Med Hyg. 2022; .

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Cadavid Restrepo A, Gass K, Won K, Sheel M, Robinson K, Graves P Int J Infect Dis. 2022; 117:378-386.

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