Molecular Insights Into Memory-Enhancing Metabolites of Nicotine in Brain: A Systematic Review

Overview

Journal Front Neurosci

Date 2019 Jan 31

PMID 30697142

Citations 11

Authors

Alireza Majdi

Farzin Kamari

Saeed Sadigh-Eteghad

Albert Gjedde

Affiliations

Soon will be listed here.

Abstract

The alleged procognitive effects of nicotine and its metabolites in brain are controversial. Here, we review the pharmacologically active metabolites of nicotine in brain and their effects on neuronal mechanisms involving two main cognitive domains, i.e., learning and memory. We searched Embase, Medline via PubMed, Scopus, and Web of Science databases for entries no later than May 2018, and restricted the search to articles about nicotine metabolites and cognitive behavior or cognitive mechanisms. The initial search yielded 425 articles, of which 17 were eligible for inclusion after application of exclusion criteria. Of these, 13 were experimental, two were clinical, and two were conference papers. The results revealed three pharmacologically active biotransformations of nicotine in the brain, including cotinine, norcotinine, and nornicotine, among which cotinine and nornicotine both had a procognitive impact without adverse effects. The observed effect was significant only for cotinine.

Citing Articles

Methoxsalen Inhibits the Acquisition of Nicotine Self-Administration: Attenuation by Cotinine Replacement in Male Rats.

Ding Z, Neslund E, Sun D, Tan X Nicotine Tob Res. 2024; 26(9):1234-1243.

PMID: 38513068 PMC: 11339168. DOI: 10.1093/ntr/ntae063.

Nicotine is associated with smoking dependence and vascular inflammation through cotinine: A mediation analysis.

Kumboyono K, Chomsy I, Shalshabilla N, Sujuti H, Srihardyastutie A, Tjahjono C Tob Induc Dis. 2024; 22.

PMID: 38250634 PMC: 10798223. DOI: 10.18332/tid/171356.

Editorial: Nicotine and its derivatives in disorders of cognition: a challenging new topic of study.

Gjedde A Front Neurosci. 2023; 17:1252705.

PMID: 37534040 PMC: 10393245. DOI: 10.3389/fnins.2023.1252705.

Nicotinic acetylcholine receptors and learning and memory deficits in Neuroinflammatory diseases.

Echeverria V, Mendoza C, Iarkov A Front Neurosci. 2023; 17:1179611.

PMID: 37255751 PMC: 10225599. DOI: 10.3389/fnins.2023.1179611.

The co-use of nicotine and prescription psychostimulants: A review of their behavioral and neuropharmacological interactions.

McNealy K, Weyrich L, Bevins R Drug Alcohol Depend. 2023; 248:109906.

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