SLIME: Robust, High-speed 3D Microvascular Mapping

Overview

Journal Sci Rep

Specialty Science

Date 2019 Jan 31

PMID 30696870

Citations 5

Authors

Yehe Liu

Meredith C G Broberg

Michiko Watanabe

Andrew M Rollins

Michael W Jenkins

Affiliations

Soon will be listed here.

Abstract

Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost approach that does not require in-depth OCT knowledge. The new method enables fast 3D microvascular mapping in large tissue volumes, providing a promising tool for investigating organ level microvascular abnormalities in large cohorts.

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