A Guide to Yellow Oral Mucosal Entities: Etiology and Pathology

Overview

Journal Head Neck Pathol

Specialties Oncology
Pathology

Date 2019 Jan 30

PMID 30693453

Citations 5

Authors

Duane R Schafer

Sarah H Glass

Affiliations

Soon will be listed here.

Abstract

When faced with an uncertain clinical pathosis in the oral cavity, identifying the color of the mucosal lesion helps to narrow down a differential diagnosis. Although less common than red and white lesions, yellow lesions encompass a small group of distinct mucosal pathologic entities. Adipose tissue, lymphoid tissue, and sebaceous glands are naturally occurring yellow constituents of the oral cavity and become apparent with associated developmental or neoplastic lesions. Reactive and inflammatory lesions can create a yellow hue due to purulence, necrosis, and calcification. Some systemic diseases are known to deposit yellow bi-products such as amyloid or bilirubin into the oral mucosa of an affected person, and while not always yellow, unusual entities like verruciform xanthoma and granular cell tumor fall under the umbrella of yellow lesions given their occasional propensity to demonstration the color. This chapter aims to explore the unique group that is yellow lesions presenting in the oral mucosa.

Citing Articles

Oral Verruciform Xanthoma of the Lower Lip: A Rare Entity.

Chatterjee A, Purkait S, Banerjee I, Banerjee A, Ramalingam K Cureus. 2024; 16(11):e73352.

PMID: 39659335 PMC: 11628199. DOI: 10.7759/cureus.73352.

Oral granular cell tumor: a collaborative clinicopathological study of 61 cases.

Aragao H, Lima L, Cavalcante I, da Silva Neto S, Turatti E, Cavalcante R Oral Maxillofac Surg. 2024; 28(3):1383-1397.

PMID: 38904898 DOI: 10.1007/s10006-024-01272-9.

Oral Lymphoepithelial Cyst: A Collaborative Clinicopathologic Study of 132 Cases from Brazil.

Cunha J, Roza A, Sousa Cruz V, Ribeiro J, Cavalcante I, Cavalcante R Head Neck Pathol. 2021; 16(1):268-277.

PMID: 34185247 PMC: 9018938. DOI: 10.1007/s12105-021-01352-2.

Occurrence of Recurrent Aphthous Stomatitis (RAS) as a Rare Oral Manifestation in a Patient with Gilbert's Syndrome.

Heboyan A, Avetisyan A, Skallevold H, Rokaya D, Marla V, Vardanyan A Case Rep Dent. 2021; 2021:6648729.

PMID: 33953989 PMC: 8068538. DOI: 10.1155/2021/6648729.

Oral Verruciform Xanthoma: A Series of 212 Cases and Review of the Literature.

Belknap A, Islam M, Bhattacharyya I, Cohen D, Fitzpatrick S Head Neck Pathol. 2020; 14(3):742-748.

PMID: 31898056 PMC: 7413928. DOI: 10.1007/s12105-019-01123-0.

References

Mannes K, Dekle C, Requena L, Sangueza O . Verruciform xanthoma associated with squamous cell carcinoma. Am J Dermatopathol. 1999; 21(1):66-9. DOI: 10.1097/00000372-199902000-00015. View

Zenk J, Constantinidis J, Kydles S, Hornung J, Iro H . [Clinical and diagnostic findings of sialolithiasis]. HNO. 1999; 47(11):963-9. DOI: 10.1007/s001060050476. View

Herrera D, Roldan S, Sanz M . The periodontal abscess: a review. J Clin Periodontol. 2000; 27(6):377-86. DOI: 10.1034/j.1600-051x.2000.027006377.x. View

Marchal F, Kurt A, Dulguerov P, Lehmann W . Retrograde theory in sialolithiasis formation. Arch Otolaryngol Head Neck Surg. 2001; 127(1):66-8. DOI: 10.1001/archotol.127.1.66. View

Philipsen H, Reichart P, Takata T, Ogawa I . Verruciform xanthoma--biological profile of 282 oral lesions based on a literature survey with nine new cases from Japan. Oral Oncol. 2003; 39(4):325-36. DOI: 10.1016/s1368-8375(02)00088-x. View

Stoopler E, Sollecito T, Chen S . Amyloid deposition in the oral cavity: a retrospective study and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 95(6):674-80. DOI: 10.1067/moe.2003.136. View

Grases F, Santiago C, Simonet B, Costa-Bauza A . Sialolithiasis: mechanism of calculi formation and etiologic factors. Clin Chim Acta. 2003; 334(1-2):131-6. DOI: 10.1016/s0009-8981(03)00227-4. View

Meyer I . Dermoid cysts (dermoids) of the floor of the mouth. Oral Surg Oral Med Oral Pathol. 1955; 8(11):1149-64. DOI: 10.1016/0030-4220(55)90380-7. View

Gold C . Branchial cleft cyst located in the floor of the mouth. Report of a case. Oral Surg Oral Med Oral Pathol. 1962; 15:1118-20. DOI: 10.1016/0030-4220(62)90311-0. View

10.

Williams M, Brown H . The adequacy of gross pathological examination of routine tonsils and adenoids in patients 21 years old and younger. Hum Pathol. 2003; 34(10):1053-7. DOI: 10.1053/s0046-8177(03)00408-8. View

11.

Furlong M, Fanburg-Smith J, Childers E . Lipoma of the oral and maxillofacial region: Site and subclassification of 125 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 98(4):441-50. DOI: 10.1016/j.tripleo.2004.02.071. View

12.

de Felice C, Parrini S, Chitano G, Gentile M, Dipaola L, Latini G . Fordyce granules and hereditary non-polyposis colorectal cancer syndrome. Gut. 2005; 54(9):1279-82. PMC: 1774669. DOI: 10.1136/gut.2005.064881. View

13.

Pryor S, Lewis J, Weaver A, Orvidas L . Pediatric dermoid cysts of the head and neck. Otolaryngol Head Neck Surg. 2005; 132(6):938-42. DOI: 10.1016/j.otohns.2005.03.005. View

14.

Tosios K, Rallis G, Vallianatou D, Vlachodimitropoulos D . Yellow-white tumor on the floor of the mouth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(6):701-4. DOI: 10.1016/j.tripleo.2005.10.066. View

15.

Rawal S, Kalmar J, Tatakis D . Verruciform xanthoma: immunohistochemical characterization of xanthoma cell phenotypes. J Periodontol. 2007; 78(3):504-9. DOI: 10.1902/jop.2007.060196. View

16.

Daley T, Armstrong J . Oral manifestations of gastrointestinal diseases. Can J Gastroenterol. 2007; 21(4):241-4. PMC: 2657699. DOI: 10.1155/2007/952673. View

17.

Gomez I, Varela P, Romero A, Garcia M, Suarez M, Seoane J . Yellowish lesions of the oral cavity. Suggestion for a classification. Med Oral Patol Oral Cir Bucal. 2007; 12(4):E272-6. View

18.

Azevedo R, Almeida O, Netto J, Miranda A, Santos T, Coletta R . Comparative clinicopathological study of intraoral sebaceous hyperplasia and sebaceous adenoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 107(1):100-4. DOI: 10.1016/j.tripleo.2008.09.027. View

19.

Jham B, Binmadi N, Scheper M, Zhao X, Koterwas G, Kashyap A . Follicular lymphoid hyperplasia of the palate: case report and literature review. J Craniomaxillofac Surg. 2009; 37(2):79-82. DOI: 10.1016/j.jcms.2008.11.007. View

20.

Vered M, Carpenter W, Buchner A . Granular cell tumor of the oral cavity: updated immunohistochemical profile. J Oral Pathol Med. 2009; 38(1):150-9. DOI: 10.1111/j.1600-0714.2008.00725.x. View