Human T Cell Leukemia Virus Type 1 and Zika Virus: Tale of Two Reemerging Viruses with Neuropathological Sequelae of Public Health Concern

Overview

Journal J Neurovirol

Publisher Springer

Specialties Microbiology
Neurology

Date 2019 Jan 30

PMID 30693421

Citations 1

Authors

DeGaulle I Chigbu

Pooja Jain

Brenndan L Crumley

Dip Patel

Zafar K Khan

Affiliations

Soon will be listed here.

Abstract

Human T cell leukemia virus type 1 (HTLV-1) and Zika virus (ZIKV) have been considered neglected viruses of low public health concern until recently when incidences of HTLV-1 and ZIKV were observed to be linked to serious immune-related disease and neurological complications. This review will discuss the epidemiology, genomic evolution, virus-host interactions, virulence factors, neuropathological sequelae, and current perspectives of these reemerging viruses. There are no FDA-approved therapeutics or vaccines against these viruses, and as such, it is important for clinical trials to focus on developing vaccines that can induce cell-mediated immune response to confer long-term protective immunity. Furthermore, attention should be paid to reducing the transmission of these viruses through unprotected sex, infected blood during sharing of contaminated needles, donated blood and organs, and vertical transmission from mother to baby via breastfeeding. There is an urgent need to re-evaluate repurposing current antiviral therapies as well as developing novel antiviral agents with enhanced efficacy due to the high morbidity rate associated with these two reemerging chronic viral diseases.

Citing Articles

Pathogenesis and Manifestations of Zika Virus-Associated Ocular Diseases.

Labib B, Chigbu D Trop Med Infect Dis. 2022; 7(6).

PMID: 35736984 PMC: 9229560. DOI: 10.3390/tropicalmed7060106.

References

Petersen L, Jamieson D, Powers A, Honein M . Zika Virus. N Engl J Med. 2016; 374(16):1552-63. DOI: 10.1056/NEJMra1602113. View

Philip S, Zahoor M, Zhi H, Ho Y, Giam C . Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex. PLoS Pathog. 2014; 10(4):e1004040. PMC: 3974842. DOI: 10.1371/journal.ppat.1004040. View

Kumar A, Hou S, Airo A, Limonta D, Mancinelli V, Branton W . Zika virus inhibits type-I interferon production and downstream signaling. EMBO Rep. 2016; 17(12):1766-1775. PMC: 5283583. DOI: 10.15252/embr.201642627. View

Retallack H, Di Lullo E, Arias C, Knopp K, Laurie M, Sandoval-Espinosa C . Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proc Natl Acad Sci U S A. 2016; 113(50):14408-14413. PMC: 5167169. DOI: 10.1073/pnas.1618029113. View

Kannagi M, Hasegawa A, Takamori A, Kinpara S, Utsunomiya A . The roles of acquired and innate immunity in human T-cell leukemia virus type 1-mediated diseases. Front Microbiol. 2012; 3:323. PMC: 3432515. DOI: 10.3389/fmicb.2012.00323. View

Kramer A, Maloney E, Morgan O, Rodgers-Johnson P, Manns A, Murphy E . Risk factors and cofactors for human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Jamaica. Am J Epidemiol. 1995; 142(11):1212-20. DOI: 10.1093/oxfordjournals.aje.a117580. View

Calvet G, Aguiar R, Melo A, Sampaio S, de Filippis I, Fabri A . Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016; 16(6):653-660. DOI: 10.1016/S1473-3099(16)00095-5. View

Maharajan M, Ranjan A, Chu J, Foo W, Chai Z, Lau E . Zika Virus Infection: Current Concerns and Perspectives. Clin Rev Allergy Immunol. 2016; 51(3):383-394. DOI: 10.1007/s12016-016-8554-7. View

Wen Z, Song H, Ming G . How does Zika virus cause microcephaly?. Genes Dev. 2017; 31(9):849-861. PMC: 5458753. DOI: 10.1101/gad.298216.117. View

10.

Routhu N, Byrareddy S . Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis. J Neuroimmune Pharmacol. 2017; 12(2):219-232. PMC: 5432125. DOI: 10.1007/s11481-017-9736-7. View

11.

Slater C, Ribeiro L, Puccioni-Sohler M . Difficulties in HAM/TSP diagnosis. Arq Neuropsiquiatr. 2012; 70(9):686-90. DOI: 10.1590/s0004-282x2012000900007. View

12.

Rahman S, Quann K, Pandya D, Singh S, Khan Z, Jain P . HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter. PLoS One. 2012; 7(4):e34490. PMC: 3319589. DOI: 10.1371/journal.pone.0034490. View

13.

Balmaseda A, Zambrana J, Collado D, Garcia N, Saborio S, Elizondo D . Comparison of Four Serological Methods and Two Reverse Transcription-PCR Assays for Diagnosis and Surveillance of Zika Virus Infection. J Clin Microbiol. 2018; 56(3). PMC: 5824050. DOI: 10.1128/JCM.01785-17. View

14.

Alberto da Silva Dias G, Sousa R, Gomes L, Muniz Caldas C, Nassiri R, Quaresma J . Correlation between clinical symptoms and peripheral immune response in HAM/TSP. Microb Pathog. 2015; 92:72-75. DOI: 10.1016/j.micpath.2015.11.018. View

15.

Shankar A, Patil A, Skariyachan S . Recent Perspectives on Genome, Transmission, Clinical Manifestation, Diagnosis, Therapeutic Strategies, Vaccine Developments, and Challenges of Zika Virus Research. Front Microbiol. 2017; 8:1761. PMC: 5603822. DOI: 10.3389/fmicb.2017.01761. View

16.

Yakob L, Walker T . Zika virus outbreak in the Americas: the need for novel mosquito control methods. Lancet Glob Health. 2016; 4(3):e148-9. DOI: 10.1016/S2214-109X(16)00048-6. View

17.

Ferreira Jr O, Planelles V, Rosenblatt J . Human T-cell leukemia viruses: epidemiology, biology, and pathogenesis. Blood Rev. 1997; 11(2):91-104. DOI: 10.1016/s0268-960x(97)90015-1. View

18.

Sugata K, Satou Y, Yasunaga J, Hara H, Ohshima K, Utsunomiya A . HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines. Blood. 2011; 119(2):434-44. PMC: 3257009. DOI: 10.1182/blood-2011-05-357459. View

19.

Rafatpanah H, Hosseini R, Pourseyed S . The Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Iran J Basic Med Sci. 2014; 16(3):235-41. PMC: 3881240. View

20.

Paiva A, Assone T, Haziot M, Smid J, Fonseca L, Luiz O . Risk factors associated with HTLV-1 vertical transmission in Brazil: longer breastfeeding, higher maternal proviral load and previous HTLV-1-infected offspring. Sci Rep. 2018; 8(1):7742. PMC: 5958084. DOI: 10.1038/s41598-018-25939-y. View