Asthma and Corticosteroid Responses in Childhood and Adult Asthma

Overview

Journal Clin Chest Med

Specialty Pulmonary Medicine

Date 2019 Jan 30

PMID 30691710

Citations 25

Authors

Amira Ali Ramadan

Jonathan M Gaffin

Elliot Israel

Wanda Phipatanakul

Affiliations

Soon will be listed here.

Abstract

Corticosteroids are the most effective treatment for asthma; inhaled corticosteroids (ICSs) are the first-line treatment for children and adults with persistent symptoms. ICSs are associated with significant improvements in lung function. The anti-inflammatory effects of corticosteroids are mediated by both genomic and nongenomic factors. Variation in the response to corticosteroids has been observed. Patient characteristics, biomarkers, and genetic features may be used to predict response to ICSs. The existence of multiple mechanisms underlying glucocorticoid insensitivity raises the possibility that this might indeed reflect different diseases with a common phenotype.

Citing Articles

Association between dietary carotenoid intakes and the risk of asthma in children and adolescents: evidence from the National Health and Nutrition Examination Survey 2007-2016.

He F, Zhang Y, Ming L Transl Pediatr. 2024; 13(7):1141-1151.

PMID: 39144429 PMC: 11319997. DOI: 10.21037/tp-24-117.

Participant Perspectives on the Implementation of a School-Linked Text-Message Intervention to Improve Pediatric Asthma Medication Adherence.

Radu S, Zarinafsar S, Ryan G, Chainani S, Becker S, Arenas J Pediatr Allergy Immunol Pulmonol. 2024; 37(1):13-21.

PMID: 38324020 PMC: 10951618. DOI: 10.1089/ped.2023.0093.

The functional role of CST1 and CCL26 in asthma development.

Hoyer A, Chakraborty S, Lilienthal I, Konradsen J, Katayama S, Soderhall C Immun Inflamm Dis. 2024; 12(1):e1162.

PMID: 38270326 PMC: 10797655. DOI: 10.1002/iid3.1162.

Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics.

Barosova R, Baranovicova E, Hanusrichterova J, Mokra D Int J Mol Sci. 2024; 25(1).

PMID: 38203630 PMC: 10779398. DOI: 10.3390/ijms25010459.

Comparison with gastric cancer-associated genes reveals the role of ferroptosis-related genes in eosinophils of asthma patients: A bioinformatic study.

Niu J, Guo W, Lu A, Han G, Wang G, Peng B Medicine (Baltimore). 2023; 102(41):e35002.

PMID: 37832131 PMC: 10578675. DOI: 10.1097/MD.0000000000035002.

References

Tantisira K, Lazarus R, Litonjua A, Klanderman B, Weiss S . Chromosome 17: association of a large inversion polymorphism with corticosteroid response in asthma. Pharmacogenet Genomics. 2008; 18(8):733-7. PMC: 3225071. DOI: 10.1097/FPC.0b013e3282fe6ebf. View

Peters-Golden M, Swern A, Bird S, Hustad C, Grant E, Edelman J . Influence of body mass index on the response to asthma controller agents. Eur Respir J. 2006; 27(3):495-503. DOI: 10.1183/09031936.06.00077205. View

Galant S, Morphew T, Guijon O, Pham L . The bronchodilator response as a predictor of inhaled corticosteroid responsiveness in asthmatic children with normal baseline spirometry. Pediatr Pulmonol. 2014; 49(12):1162-9. DOI: 10.1002/ppul.22957. View

Dunican E, Fahy J . Asthma and corticosteroids: time for a more precise approach to treatment. Eur Respir J. 2017; 49(6). DOI: 10.1183/13993003.01167-2017. View

Fergeson J, Patel S, Lockey R . Acute asthma, prognosis, and treatment. J Allergy Clin Immunol. 2016; 139(2):438-447. DOI: 10.1016/j.jaci.2016.06.054. View

Kupczyk M, Haque S, Middelveld R, Dahlen B, Dahlen S . Phenotypic predictors of response to oral glucocorticosteroids in severe asthma. Respir Med. 2013; 107(10):1521-30. DOI: 10.1016/j.rmed.2013.07.014. View

Mosteller M, Hosking L, Murphy K, Shen J, Song K, Nelson M . No evidence of large genetic effects on steroid response in asthma patients. J Allergy Clin Immunol. 2016; 139(3):797-803.e7. DOI: 10.1016/j.jaci.2016.05.032. View

Inglis G, Ingram M, Holloway C, Swan L, Birnie D, Hillis W . Familial pattern of corticosteroids and their metabolism in adult human subjects--the Scottish Adult Twin Study. J Clin Endocrinol Metab. 1999; 84(11):4132-7. DOI: 10.1210/jcem.84.11.6146. View

Chalmers G, MacLeod K, Thomson L, Little S, McSharry C, Thomson N . Smoking and airway inflammation in patients with mild asthma. Chest. 2001; 120(6):1917-22. DOI: 10.1378/chest.120.6.1917. View

10.

Szefler S, Phillips B, Martinez F, Chinchilli V, Lemanske R, Strunk R . Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol. 2005; 115(2):233-42. DOI: 10.1016/j.jaci.2004.11.014. View

11.

Baye T, Abebe T, Wilke R . Genotype-environment interactions and their translational implications. Per Med. 2011; 8(1):59-70. PMC: 3108095. DOI: 10.2217/pme.10.75. View

12.

Fitzpatrick A, Jackson D, Mauger D, Boehmer S, Phipatanakul W, Sheehan W . Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol. 2016; 138(6):1608-1618.e12. PMC: 5148729. DOI: 10.1016/j.jaci.2016.09.028. View

13.

Klok T, Kaptein A, Brand P . Non-adherence in children with asthma reviewed: The need for improvement of asthma care and medical education. Pediatr Allergy Immunol. 2015; 26(3):197-205. DOI: 10.1111/pai.12362. View

14.

Bacharier L, Strunk R, Mauger D, White D, Lemanske Jr R, Sorkness C . Classifying asthma severity in children: mismatch between symptoms, medication use, and lung function. Am J Respir Crit Care Med. 2004; 170(4):426-32. DOI: 10.1164/rccm.200308-1178OC. View

15.

Szefler S, Martin R . Lessons learned from variation in response to therapy in clinical trials. J Allergy Clin Immunol. 2010; 125(2):285-92. PMC: 2904979. DOI: 10.1016/j.jaci.2009.10.026. View

16.

Szefler S, Wenzel S, Brown R, Erzurum S, Fahy J, Hamilton R . Asthma outcomes: biomarkers. J Allergy Clin Immunol. 2012; 129(3 Suppl):S9-23. PMC: 3390196. DOI: 10.1016/j.jaci.2011.12.979. View

17.

Tantisira K, Lasky-Su J, Harada M, Murphy A, Litonjua A, Himes B . Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med. 2011; 365(13):1173-83. PMC: 3667396. DOI: 10.1056/NEJMoa0911353. View

18.

Leusink M, Vijverberg S, Koenderman L, Raaijmakers J, de Jongste J, Sterk P . Genetic variation in uncontrolled childhood asthma despite ICS treatment. Pharmacogenomics J. 2015; 16(2):158-63. DOI: 10.1038/tpj.2015.36. View

19.

Little S, Chalmers G, MacLeod K, McSharry C, Thomson N . Non-invasive markers of airway inflammation as predictors of oral steroid responsiveness in asthma. Thorax. 2000; 55(3):232-4. PMC: 1745700. DOI: 10.1136/thorax.55.3.232. View

20.

Bossley C, Fleming L, Ullmann N, Gupta A, Adams A, Nagakumar P . Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach. J Allergy Clin Immunol. 2016; 138(2):413-420.e6. DOI: 10.1016/j.jaci.2015.12.1347. View