» Articles » PMID: 30689983

Principles and Practice of Antibiotic Stewardship in the ICU

Overview
Journal Chest
Publisher Elsevier
Specialty Pulmonary Medicine
Date 2019 Jan 29
PMID 30689983
Citations 39
Authors
Affiliations
Soon will be listed here.
Abstract

In the face of emerging drug-resistant pathogens and a decrease in the development of new antimicrobial agents, antibiotic stewardship should be practiced in all critical care units. Antibiotic stewardship should be a core competency of all critical care practitioners in conjunction with a formal antibiotic stewardship program (ASP). Prospective audit and feedback, and antibiotic time-outs, are effective components of an ASP in the ICU. As rapid diagnostics are introduced in the ICU, assessment of performance and effect on outcomes will clearly be needed. Disease-specific stewardship for community-acquired pneumonia that relies on clinical pathways may be particularly high-yield. Computerized decision support has the potential to individualize stewardship for specific patients. Finally, infection control and prevention is the cornerstone of every ASP.

Citing Articles

Efficacy of quality improvement interventions on antibiotic prescription practices for ventilator-associated pneumonia at a tertiary care centre: a prospective pre-post interventional study.

Kumar V, Biswas R, Ojha V, Kumar S, Sarfraz A BMJ Open Qual. 2024; 13(4.

PMID: 39709191 PMC: 11667312. DOI: 10.1136/bmjoq-2024-002926.


Retrospective ANalysis of multi-drug resistant Gram-nEgative bacteRia on veno-venous extracorporeal membrane oxygenation. The multicenter RANGER STUDY.

Boscolo A, Bruni A, Giani M, Garofalo E, Sella N, Pettenuzzo T Crit Care. 2024; 28(1):279.

PMID: 39192287 PMC: 11351604. DOI: 10.1186/s13054-024-05068-x.


Improvement in Diagnosis and Management of Nosocomial Pneumonias in a Cardiovascular Surgery Intensive Care Unit: A Multidisciplinary Approach.

Kooda K, Zambrano A, Kosaski D, Higbe L, Beam W, Bohman J Antibiotics (Basel). 2024; 13(7).

PMID: 39061272 PMC: 11274194. DOI: 10.3390/antibiotics13070590.


The Impact of Next-Generation Sequencing Added to Multiplex PCR on Antibiotic Stewardship in Critically Ill Patients with Suspected Pneumonia.

Kling K, Qi C, Wunderink R, Pickens C Diagnostics (Basel). 2024; 14(13.

PMID: 39001278 PMC: 11241116. DOI: 10.3390/diagnostics14131388.


Empirical antifungal therapy for health care-associated intra-abdominal infection: a retrospective, multicentre and comparative study.

Mokart D, Boutaba M, Servan L, Bertrand B, Baldesi O, Lefebvre L Ann Intensive Care. 2024; 14(1):98.

PMID: 38916830 PMC: 11199462. DOI: 10.1186/s13613-024-01333-y.


References
1.
Gums J, Yancey Jr R, Hamilton C, Kubilis P . A randomized, prospective study measuring outcomes after antibiotic therapy intervention by a multidisciplinary consult team. Pharmacotherapy. 1999; 19(12):1369-77. DOI: 10.1592/phco.19.18.1369.30898. View

2.
Leone M, Malavieille F, Papazian L, Meyssignac B, Cassir N, Textoris J . Routine use of Staphylococcus aureus rapid diagnostic test in patients with suspected ventilator-associated pneumonia. Crit Care. 2013; 17(4):R170. PMC: 4056790. DOI: 10.1186/cc12849. View

3.
Schwartz B, Bell D, Hughes J . Preventing the emergence of antimicrobial resistance. A call for action by clinicians, public health officials, and patients. JAMA. 1997; 278(11):944-5. DOI: 10.1001/jama.278.11.944. View

4.
Pittet D, Dharan S, Touveneau S, Sauvan V, Perneger T . Bacterial contamination of the hands of hospital staff during routine patient care. Arch Intern Med. 1999; 159(8):821-6. DOI: 10.1001/archinte.159.8.821. View

5.
Lopez Roa P, Rodriguez-Sanchez B, Catalan P, Giannella M, Alcala L, Padilla B . Diagnosis of influenza in intensive care units: lower respiratory tract samples are better than nose-throat swabs. Am J Respir Crit Care Med. 2012; 186(9):929-30. DOI: 10.1164/ajrccm.186.9.929. View