FEF Excitability in Attentional Bias: A TMS-EEG Study

Overview

Journal Front Behav Neurosci

Specialty Psychology

Date 2019 Jan 29

PMID 30687035

Citations 3

Authors

Sara Torriero

Giulia Mattavelli

Emanuele Lo Gerfo

Leonor Romero Lauro

Rossana Actis-Grosso

Paola Ricciardelli

Affiliations

Soon will be listed here.

Abstract

The role of distinct cortical regions in guiding social orienting needs further investigation. Our aim was to explore the contribution of the frontal eye field (FEF) in early orienting of attention towards stimuli with social value. We used a TMS-EEG approach to investigate event related potentials (ERPs; no-TMS block) and TMS evoked potentials (TEPs; TMS block) during the cueing phase of a modified version of the dot-probe task, comparing competing (face vs. house) and not competing (house vs. house) conditions. Our results revealed an increased amplitude of ERP components in the competing condition, showing greater posterior N170 and fronto-central vertex positive potential (VPP) and an enhanced frontal negative component at 250-270 ms from cue onset. TMS pulses over the FEF induced similar N170 and VPP amplified components. In addition, in the ERPs, a reduced positivity at 400 ms was shown when the face appeared on the left side vs. the right side of space. In contrast, in the TMS blocks, we found lateralized effects on N170 depending on the side of face presentation. The enhanced cortical excitability induced by TMS over the right FEF significantly correlated with the performance on the behavioral task, suggesting a link between the FEF activity during the cueing phase of the dot-probe task and the subsequent behavioral response times to the targets.

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References

MacLeod C, Mathews A, Tata P . Attentional bias in emotional disorders. J Abnorm Psychol. 1986; 95(1):15-20. DOI: 10.1037//0021-843x.95.1.15. View

Corbetta M, Patel G, Shulman G . The reorienting system of the human brain: from environment to theory of mind. Neuron. 2008; 58(3):306-24. PMC: 2441869. DOI: 10.1016/j.neuron.2008.04.017. View

Chica A, Lasaponara S, Chanes L, Valero-Cabre A, Doricchi F, Lupianez J . Spatial attention and conscious perception: the role of endogenous and exogenous orienting. Atten Percept Psychophys. 2011; 73(4):1065-81. DOI: 10.3758/s13414-010-0082-6. View

Bindemann M, Burton A, Langton S, Schweinberger S, Doherty M . The control of attention to faces. J Vis. 2007; 7(10):15.1-8. DOI: 10.1167/7.10.15. View

Mogg K, Bradley B, Hallowell N . Attentional bias to threat: roles of trait anxiety, stressful events, and awareness. Q J Exp Psychol A. 1994; 47(4):841-64. DOI: 10.1080/14640749408401099. View

Mattavelli G, Cattaneo Z, Papagno C . Transcranial magnetic stimulation of medial prefrontal cortex modulates face expressions processing in a priming task. Neuropsychologia. 2011; 49(5):992-998. DOI: 10.1016/j.neuropsychologia.2011.01.038. View

Holmes A, Mogg K, Monje Garcia L, Bradley B . Neural activity associated with attention orienting triggered by gaze cues: A study of lateralized ERPs. Soc Neurosci. 2010; 5(3):285-95. DOI: 10.1080/17470910903422819. View

Suwazono S, Machado L, Knight R . Predictive value of novel stimuli modifies visual event-related potentials and behavior. Clin Neurophysiol. 2000; 111(1):29-39. DOI: 10.1016/s1388-2457(99)00186-8. View

Lauro L, Rosanova M, Mattavelli G, Convento S, Pisoni A, Opitz A . TDCS increases cortical excitability: direct evidence from TMS-EEG. Cortex. 2014; 58:99-111. DOI: 10.1016/j.cortex.2014.05.003. View

10.

Taylor P, Nobre A, Rushworth M . FEF TMS affects visual cortical activity. Cereb Cortex. 2006; 17(2):391-9. DOI: 10.1093/cercor/bhj156. View

11.

Marshall T, OShea J, Jensen O, Bergmann T . Frontal eye fields control attentional modulation of alpha and gamma oscillations in contralateral occipitoparietal cortex. J Neurosci. 2015; 35(4):1638-47. PMC: 4308606. DOI: 10.1523/JNEUROSCI.3116-14.2015. View

12.

Pourtois G, Vuilleumier P . Dynamics of emotional effects on spatial attention in the human visual cortex. Prog Brain Res. 2006; 156:67-91. DOI: 10.1016/S0079-6123(06)56004-2. View

13.

Torrence R, Troup L . Event-related potentials of attentional bias toward faces in the dot-probe task: A systematic review. Psychophysiology. 2017; 55(6):e13051. DOI: 10.1111/psyp.13051. View

14.

Bentin S, Allison T, Puce A, Perez E, McCarthy G . Electrophysiological Studies of Face Perception in Humans. J Cogn Neurosci. 2010; 8(6):551-565. PMC: 2927138. DOI: 10.1162/jocn.1996.8.6.551. View

15.

Wiese E, Abubshait A, Azarian B, Blumberg E . Brain stimulation to left prefrontal cortex modulates attentional orienting to gaze cues. Philos Trans R Soc Lond B Biol Sci. 2019; 374(1771):20180430. PMC: 6452240. DOI: 10.1098/rstb.2018.0430. View

16.

Taylor P, Walsh V, Eimer M . Combining TMS and EEG to study cognitive function and cortico-cortico interactions. Behav Brain Res. 2008; 191(2):141-7. PMC: 2779459. DOI: 10.1016/j.bbr.2008.03.033. View

17.

Nobre A, Sebestyen G, Miniussi C . The dynamics of shifting visuospatial attention revealed by event-related potentials. Neuropsychologia. 2000; 38(7):964-74. DOI: 10.1016/s0028-3932(00)00015-4. View

18.

Browning M, Holmes E, Murphy S, Goodwin G, Harmer C . Lateral prefrontal cortex mediates the cognitive modification of attentional bias. Biol Psychiatry. 2009; 67(10):919-25. PMC: 2866253. DOI: 10.1016/j.biopsych.2009.10.031. View

19.

Baldauf D, Desimone R . Neural mechanisms of object-based attention. Science. 2014; 344(6182):424-7. DOI: 10.1126/science.1247003. View

20.

Eimer M, Holmes A . Event-related brain potential correlates of emotional face processing. Neuropsychologia. 2006; 45(1):15-31. PMC: 2383989. DOI: 10.1016/j.neuropsychologia.2006.04.022. View