Functional and Surface Characterisitics of Lymphocytes from Patients with Warm-antibody Type Autoimmunhemolytic Anemia (AIHA)

Overview

Journal Blut

Specialty Hematology

Date 1978 Jun 20

PMID 306850

Citations 1

Authors

J Kruger

F J Desaga

Affiliations

Soon will be listed here.

Abstract

As part of an overall assessment of immunological function, several aspects of cellular immunity and circulating lymphocyte subpopulations were evaluated in a group of 10 patients with idiopathic autoimmunhemolytic anemia (AIHA). The absolute numbers of circulating T and B cells were reduced in the patient group compared to normals. A shift from "corticosteroid-sensitive" to "corticosteroid-resistent" and activated cells in the cytogram of clustered Fe-(III)-hydroxide-glucane saccharose labeled T lymphocytes was apparent. In vitro studies of cellular reactivity, as evaluated by PHA, ConA, PWM, antigens and allogeneic cell induced proliferation showed a blend of general or selective depression and sometimes a normal or increased activity with no definite correlation with both the number of circulating T cells and the extent of the hemolytic activity by the disease. The possible significance of the findings is discussed.

Citing Articles

Thymocytotoxic antibodies in patients with autoimmune hemolytic anemia, systemic lupus erythematosus and lymphoproliferative diseases.

Fagiolo E Blut. 1982; 44(4):225-30.

PMID: 6979365 DOI: 10.1007/BF00319908.

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