The Interplay Between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Jan 27

PMID 30682772

Citations 26

Authors

Rossella Cianci

Laura Franza

Giovanni Schinzari

Ernesto Rossi

Gianluca Ianiro

Giampaolo Tortora

Antonio Gasbarrini

Giovanni Gambassi

Giovanni Cammarota

Affiliations

Soon will be listed here.

Abstract

The gut microbiota is central to the pathogenesis of several inflammatory and autoimmune diseases. While multiple mechanisms are involved, the immune system clearly plays a special role. Indeed, the breakdown of the physiological balance in gut microbial composition leads to dysbiosis, which is then able to enhance inflammation and to influence gene expression. At the same time, there is an intense cross-talk between the microbiota and the immunological niche in the intestinal mucosa. These interactions may pave the way to the development, growth and spreading of cancer, especially in the gastro-intestinal system. Here, we review the changes in microbiota composition, how they relate to the immunological imbalance, influencing the onset of different types of cancer and the impact of these mechanisms on the efficacy of traditional and upcoming cancer treatments.

Citing Articles

Exploring the Exposome Spectrum: Unveiling Endogenous and Exogenous Factors in Non-Communicable Chronic Diseases.

Di Renzo L, Gualtieri P, Frank G, Cianci R, Caldarelli M, Leggeri G Diseases. 2024; 12(8).

PMID: 39195175 PMC: 11353379. DOI: 10.3390/diseases12080176.

The Interplay between and Gut Microbiota in Non-Gastrointestinal Disorders: A Special Focus on Atherosclerosis.

Candelli M, Franza L, Cianci R, Pignataro G, Merra G, Piccioni A Int J Mol Sci. 2023; 24(24).

PMID: 38139349 PMC: 10744166. DOI: 10.3390/ijms242417520.

Gut-Kidney-Heart: A Novel Trilogy.

Caldarelli M, Franza L, Rio P, Gasbarrini A, Gambassi G, Cianci R Biomedicines. 2023; 11(11).

PMID: 38002063 PMC: 10669427. DOI: 10.3390/biomedicines11113063.

Gut microbiota and immunotherapy of renal cell carcinoma.

Bibbo S, Porcari S, Del Vecchio L, Severino A, Mullish B, Ianiro G Hum Vaccin Immunother. 2023; 19(3):2268982.

PMID: 37955340 PMC: 10653624. DOI: 10.1080/21645515.2023.2268982.

Pancreatic Ductal Adenocarcinoma and Nutrition: Exploring the Role of Diet and Gut Health.

Gualtieri P, Cianci R, Frank G, Pizzocaro E, De Santis G, Giannattasio S Nutrients. 2023; 15(20).

PMID: 37892540 PMC: 10610120. DOI: 10.3390/nu15204465.

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