Common Variants in the Gene Are Associated with Serum Uric Acid Level and Hyperuricemia and Gout in Han Chinese

Overview

Journal Hereditas

Specialty Genetics

Date 2019 Jan 26

PMID 30679935

Citations 4

Authors

Zhaowei Zhou

Zhiqiang Li

Can Wang

Xinde Li

Xiaoyu Cheng

Changgui Li

Yongyong Shi

Affiliations

Soon will be listed here.

Abstract

Background: Serum uric acid (SUA), hyperuricemia (HUA) and gout are complex traits with relatively high heritability. This study aims to identify whether a candidate gene, , exerts susceptibility for SUA fluctuation and incidence of HUA and gout in the Han Chinese population.

Results: Three sample sets of 1376 gout patients, 1290 long-term HUA subjects (no gout attack) and 1349 normouricemic controls were recruited for this study. Eight polymorphisms in the gene were genotyped using the ligase detection reaction-polymerase chain reaction (LDR-PCR) technology. Rs16941238 showed the most significant associations with SUA level (minor allele "A", BETA = - 13.84 μmol/L, = 0.0041, P = 0.0042) and HUA (OR = 0.7734, = 0.0033, P = 0.0020), but not with gout (OR = 0.8801, = 0.1315, P = 0.1491). Rs2271437 was significantly associated with gout (minor allele "G", OR = 1.387, = 0.0277, P = 0.0288), and was further confirmed in the meta-analysis with the previously published gout GWAS dataset (OR = 1.3221, = 0.0089). Each variant basically conferred consistent OR direction on gout and HUA, compared with the normouricemic control.

Conclusions: Our findings support the associations of the gene with the SUA level, the HUA phenotype and gout in Han Chinese.

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