Human Tumor Xenografts As Model for Drug Testing

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 1988 Nov 1

PMID 3067903

Citations 27

Authors

J Mattern

M Bak

E W Hahn

M Volm

Affiliations

Soon will be listed here.

Abstract

This paper reviews the history of xenografts, the endpoints commonly used to evaluate response and chemotherapeutic results obtained with serially maintained human tumor xenografts from different laboratories, and discusses the potential clinical relevance of the heterotransplant model for cancer chemotherapy. Specifically, an attempt is made to correlate the published xenograft data with the clinical data. Drug testing with different types of xenotransplanted tumors has shown that the response of xenografts obtained in immune-deficient animals is comparable to that in clinical practice. In addition, xenografts of a particular tumor type are able to identify agents of known clinical activity against that disease.

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