Critical Windows for Associations Between Manganese Exposure During Pregnancy and Size at Birth: A Longitudinal Cohort Study in Wuhan, China

Overview

Journal Environ Health Perspect

Date 2019 Jan 25

PMID 30675808

Citations 11

Authors

Jie Hu

Chuansha Wu

Tongzhang Zheng

Bin Zhang

Wei Xia

Yang Peng

Wenyu Liu

Minmin Jiang

Simin Liu

Stephen L Buka

Aifen Zhou

Yiming Zhang

Yangqian Jiang

Chen Hu

Xiaomei Chen

Qiang Zeng

Xi Chen

Bing Xu

Xichi Zhang

Ashley Truong

Kunchong Shi

Zhengmin Qian

Yuanyuan Li

Shunqing Xu

Affiliations

Soon will be listed here.

Abstract

Background: Prenatal overexposure to manganese (Mn), an essential micronutrient, is related to impaired fetal growth and development. Fetuses appear to be highly sensitive to Mn during short periods of gestation. However, little is known about the critical windows of susceptibility to Mn for humans.

Objectives: Our objective was to estimate trimester-specific associations of exposure to Mn with size at birth.

Methods: Urine samples of 3,022 women were collected repeatedly in the first, second, and third trimesters in Wuhan, China. Urinary concentrations of Mn and other toxic metals were measured using an inductively coupled plasma mass spectrometry. Trimester-specific associations of specific gravity–adjusted urinary Mn concentrations with birth weight, birth length, and ponderal index were estimated using multivariable linear regressions with generalized estimating equations. Linear mixed models were applied to evaluate the windows of susceptibility to Mn exposure by comparing the pattern of Mn exposure among newborns with restricted size at birth to those without.

Results: When compared with the third quintile of urinary Mn concentrations, both higher and lower quintiles of urinary Mn concentrations in the second and third trimesters were related to reduced birth weight, birth length, and ponderal index. But the observed associations for higher quintiles were stronger and more likely to be statistically significant [e.g., for women who were in the fifth quintile of Mn concentration in the third trimester, the reduction in birth weight was [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]) g and in birth length was [Formula: see text] (95% CI: [Formula: see text], 0.00) cm]. Moreover, newborns with restricted size at birth, compared with those without, had higher levels of Mn exposure in the second and third trimesters.

Conclusions: This prospective prenatal cohort study revealed an association of exposure to Mn during pregnancy, especially late pregnancy, with restricted size at birth. Replications are needed. https://doi.org/10.1289/EHP3423.

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References

Keen C, Ensunsa J, WATSON M, Baly D, Donovan S, Monaco M . Nutritional aspects of manganese from experimental studies. Neurotoxicology. 1999; 20(2-3):213-23. View

Smargiassi A, Mutti A . Peripheral biomarkers and exposure to manganese. Neurotoxicology. 1999; 20(2-3):401-6. View

Krachler M, Rossipal E, Micetic-Turk D . Trace element transfer from the mother to the newborn--investigations on triplets of colostrum, maternal and umbilical cord sera. Eur J Clin Nutr. 1999; 53(6):486-94. DOI: 10.1038/sj.ejcn.1600781. View

Selevan S, Kimmel C, Mendola P . Identifying critical windows of exposure for children's health. Environ Health Perspect. 2000; 108 Suppl 3:451-5. PMC: 1637810. DOI: 10.1289/ehp.00108s3451. View

Takser L, Lafond J, Bouchard M, St-Amour G, Mergler D . Manganese levels during pregnancy and at birth: relation to environmental factors and smoking in a Southwest Quebec population. Environ Res. 2004; 95(2):119-25. DOI: 10.1016/j.envres.2003.11.002. View

Duty S, Calafat A, Silva M, Ryan L, Hauser R . Phthalate exposure and reproductive hormones in adult men. Hum Reprod. 2004; 20(3):604-10. DOI: 10.1093/humrep/deh656. View

Kuzawa C . Fetal origins of developmental plasticity: are fetal cues reliable predictors of future nutritional environments?. Am J Hum Biol. 2004; 17(1):5-21. DOI: 10.1002/ajhb.20091. View

Crossgrove J, Zheng W . Manganese toxicity upon overexposure. NMR Biomed. 2004; 17(8):544-53. PMC: 3980863. DOI: 10.1002/nbm.931. View

Goulle J, Mahieu L, Castermant J, Neveu N, Bonneau L, Laine G . Metal and metalloid multi-elementary ICP-MS validation in whole blood, plasma, urine and hair. Reference values. Forensic Sci Int. 2005; 153(1):39-44. DOI: 10.1016/j.forsciint.2005.04.020. View

10.

Aschner J, Aschner M . Nutritional aspects of manganese homeostasis. Mol Aspects Med. 2005; 26(4-5):353-62. PMC: 6309959. DOI: 10.1016/j.mam.2005.07.003. View

11.

Heitland P, Koster H . Biomonitoring of 30 trace elements in urine of children and adults by ICP-MS. Clin Chim Acta. 2005; 365(1-2):310-8. DOI: 10.1016/j.cca.2005.09.013. View

12.

He Z, Yang X, Stoffella P . Trace elements in agroecosystems and impacts on the environment. J Trace Elem Med Biol. 2005; 19(2-3):125-40. DOI: 10.1016/j.jtemb.2005.02.010. View

13.

Landmann E, Reiss I, Misselwitz B, Gortner L . Ponderal index for discrimination between symmetric and asymmetric growth restriction: percentiles for neonates from 30 weeks to 43 weeks of gestation. J Matern Fetal Neonatal Med. 2006; 19(3):157-60. DOI: 10.1080/14767050600624786. View

14.

Ohashi F, Fukui Y, Takada S, Moriguchi J, Ezaki T, Ikeda M . Reference values for cobalt, copper, manganese, and nickel in urine among women of the general population in Japan. Int Arch Occup Environ Health. 2006; 80(2):117-26. DOI: 10.1007/s00420-006-0109-4. View

15.

Erikson K, Dorman D, Fitsanakis V, Lash L, Aschner M . Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese. Biol Trace Elem Res. 2006; 111(1-3):199-215. DOI: 10.1385/BTER:111:1:199. View

16.

Hansen S, Spears J, Lloyd K, Whisnant C . Feeding a low manganese diet to heifers during gestation impairs fetal growth and development. J Dairy Sci. 2006; 89(11):4305-11. DOI: 10.3168/jds.S0022-0302(06)72477-8. View

17.

Erikson K, Thompson K, Aschner J, Aschner M . Manganese neurotoxicity: a focus on the neonate. Pharmacol Ther. 2006; 113(2):369-77. PMC: 1852452. DOI: 10.1016/j.pharmthera.2006.09.002. View

18.

Barker D . The origins of the developmental origins theory. J Intern Med. 2007; 261(5):412-7. DOI: 10.1111/j.1365-2796.2007.01809.x. View

19.

Gluckman P, Hanson M, Cooper C, Thornburg K . Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008; 359(1):61-73. PMC: 3923653. DOI: 10.1056/NEJMra0708473. View

20.

Zota A, Ettinger A, Bouchard M, Amarasiriwardena C, Schwartz J, Hu H . Maternal blood manganese levels and infant birth weight. Epidemiology. 2009; 20(3):367-73. PMC: 3113478. DOI: 10.1097/EDE.0b013e31819b93c0. View