Medullary Thyroid Carcinoma: Why Is Specialization Mandatory?
Overview
Authors
Affiliations
Medullary thyroid carcinoma (MTC) represents a distinct form of thyroid cancer with a potentially aggressive behavior, early lymph node metastases, and sporadic as well as hereditary forms. Only surgery with total thyroidectomy and lymph node dissection is able to achieve biochemical cure. Due to the uncommon nature of MTC, a specialization in endocrine surgery for diagnosis as well as therapy of MTC seem to be mandatory for a successful treatment. Knowledge of genotype-phenotype correlations for hereditary forms or routine calcitonin screening for sporadic forms is important to analyze preoperative findings and plan surgical procedures. Postoperative follow-up depends on biochemical cure or monitoring for patients with elevated calcitonin levels.
The Efficacy and Safety of Anlotinib in the Treatment of Thyroid Cancer: A Systematic Review.
Muntean C, Solomon A, Cipaian R, Vonica R, Butuca A, Gaborean V J Clin Med. 2025; 14(2.
PMID: 39860342 PMC: 11765571. DOI: 10.3390/jcm14020338.
Luvhengo T, Moeng M, Sishuba N, Makgoka M, Jonas L, Mamathuntsha T Cancers (Basel). 2024; 16(20).
PMID: 39456563 PMC: 11505703. DOI: 10.3390/cancers16203469.
Management of lymph nodes in medullary thyroid carcinoma: A review.
Shaghaghi A, Salari A, Jalaeefar A, Shirkhoda M Ann Med Surg (Lond). 2022; 81:104538.
PMID: 36147070 PMC: 9486732. DOI: 10.1016/j.amsu.2022.104538.
Jiang M, Shi X, Zhu H, Wei W, Li J Med Sci Monit. 2019; 25:5170-5180.
PMID: 31298226 PMC: 6642674. DOI: 10.12659/MSM.916815.
Frontiers in Surgical Evolution: A Festschrift Honoring Ernst Klar.
Alsfasser G Visc Med. 2019; 34(6):411.
PMID: 30675483 PMC: 6341315. DOI: 10.1159/000495226.