Role of RNA-binding Protein 5 in the Diagnosis and Chemotherapeutic Response of Lung Cancer

Overview

Journal Oncol Lett

Specialty Oncology

Date 2019 Jan 25

PMID 30675268

Citations 6

Authors

Yanling Xu

Zhenzhong Su

Junyao Li

Qi Wang

Guangping Meng

Yu Zhang

Wen Yang

Jie Zhang

Peng Gao

Affiliations

Soon will be listed here.

Abstract

Lung cancer remains one of the leading causes of cancer-associated mortality in the world. Lung carcinogenesis is frequently associated with deletions or the loss of heterozygosity at the critical chromosomal region 3p21.3, where RNA-binding protein 5 (RBM5) is localized. RBM5 regulates cell growth, cell cycle progression and apoptosis in cell homeostasis. In the lungs, altered RBM5 protein expression leads to alterations in cell growth and apoptosis, with subsequent lung pathogenesis and varied responses to treatment in patients with lung cancer. Detection of RBM5 expression may be a tumor marker for diagnosis, prediction and treatment response in lung cancer, and may be developed as a potential therapeutic target for drug resistant lung cancer. This review discusses the most recent progress on the role of RBM5 in lung cancer.

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