Integrating Molecular Pathogenesis and Clinical Translation in Sepsis-induced Acute Respiratory Distress Syndrome

Overview

Journal JCI Insight

Specialties Biomedical Engineering
General Medicine

Date 2019 Jan 25

PMID 30674720

Citations 95

Authors

Joshua A Englert

Christopher Bobba

Rebecca M Baron

Affiliations

Soon will be listed here.

Abstract

Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host response to infection leads to disruption of the pulmonary alveolar-capillary barrier, resulting in lung injury characterized by hypoxemia, inflammation, and noncardiogenic pulmonary edema. Despite increased understanding of the molecular biology underlying sepsis-induced ARDS, there are no targeted pharmacologic therapies for this devastating condition. Here, we review the molecular underpinnings of sepsis-induced ARDS with a focus on relevant clinical and translational studies that point toward novel therapeutic strategies.

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