Can Ovarian Aging Be Delayed by Pharmacological Strategies?

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2019 Jan 25

PMID 30674710

Citations 29

Authors

Jinjin Zhang

Qian Chen

Dingfu Du

Tong Wu

Jingyi Wen

Meng Wu

Yan Zhang

Wei Yan

Su Zhou

Yan Li

Yan Jin

Aiyue Luo

Shixuan Wang

Affiliations

Soon will be listed here.

Abstract

Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth, compared to other organs. Ovarian aging is considered as the pacemaker of female body aging, which drives the aging of multiple organs of the body. Hence, anti-ovarian aging has become a research topic broadly interesting to both biomedical scientists and pharmaceutical industry. A marked progress has been made in exploration of possible anti-ovarian agents or approaches, such as calorie restriction mimetics, antioxidants, autophagy inducers etc., over the past years. This review is attempted to discuss recent advances in the area of anti-ovarian aging pharmacology and to offer new insights into our better understanding of molecular mechanisms underlying ovarian aging, which might be informative for future prevention and treatment of ovarian aging and its related diseases.

Citing Articles

Mitochondria: the epigenetic regulators of ovarian aging and longevity.

Mani S, Srivastava V, Shandilya C, Kaushik A, Singh K Front Endocrinol (Lausanne). 2024; 15:1424826.

PMID: 39605943 PMC: 11598335. DOI: 10.3389/fendo.2024.1424826.

Phospholipid Phosphatase 3 () Induces Oxidative Stress to Accelerate Ovarian Aging in Pigs.

Quan H, Guo Y, Li S, Jiang Y, Shen Q, He Y Cells. 2024; 13(17.

PMID: 39272993 PMC: 11394089. DOI: 10.3390/cells13171421.

Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.

Li J, Liu Y, He J, Wu Z, Wang F, Huang J J Ovarian Res. 2024; 17(1):35.

PMID: 38317224 PMC: 10845654. DOI: 10.1186/s13048-024-01348-w.

Differential analysis of ovarian tissue between high and low-yielded laying hens in the late laying stage and the effect of LECT2 gene on follicular granulosa cells proliferation.

Chen L, Li X, Wu Y, Wang J, Pi J Mol Biol Rep. 2024; 51(1):240.

PMID: 38300380 DOI: 10.1007/s11033-024-09260-8.

Sestrin1, 2, and 3 are dispensable for female fertility in mice.

Wang M, Chen W, Zeng X, Wang T, Sun Y, Yang Q J Ovarian Res. 2024; 17(1):28.

PMID: 38297375 PMC: 10832176. DOI: 10.1186/s13048-024-01345-z.

References

Stadtmauer L, Vidali A, Lindheim S, Sauer M . Follicular fluid insulin-like growth factor-I and insulin-like growth factor-binding protein-1 and -3 vary as a function of ovarian reserve and ovarian stimulation. J Assist Reprod Genet. 1998; 15(10):587-93. PMC: 3454853. DOI: 10.1023/a:1020377209952. View

Sugiyama M, Kawahara-Miki R, Kawana H, Shirasuna K, Kuwayama T, Iwata H . Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from early antral follicles of aged cows. J Reprod Dev. 2015; 61(4):251-9. PMC: 4547982. DOI: 10.1262/jrd.2015-001. View

Zhang J, Fang L, Shi L, Lai Z, Lu Z, Xiong J . Protective effects and mechanisms investigation of Kuntai capsule on the ovarian function of a novel model with accelerated aging ovaries. J Ethnopharmacol. 2016; 195:173-181. DOI: 10.1016/j.jep.2016.11.014. View

Place N, Tuthill C, Schoomer E, Tramontin A, Zucker I . Short day lengths delay reproductive aging. Biol Reprod. 2004; 71(3):987-92. DOI: 10.1095/biolreprod.104.029900. View

Kikuchi N, Andoh K, Abe Y, Yamada K, Mizunuma H, Ibuki Y . Inhibitory action of leptin on early follicular growth differs in immature and adult female mice. Biol Reprod. 2001; 65(1):66-71. DOI: 10.1095/biolreprod65.1.66. View

Xia T, Fu Y, Li S, Ma R, Zhao Z, Wang B . Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway. J Assist Reprod Genet. 2016; 33(6):795-805. PMC: 4889480. DOI: 10.1007/s10815-016-0697-1. View

Harman D . Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956; 11(3):298-300. DOI: 10.1093/geronj/11.3.298. View

Kapahi P, Zid B, Harper T, Koslover D, Sapin V, Benzer S . Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004; 14(10):885-90. PMC: 2754830. DOI: 10.1016/j.cub.2004.03.059. View

Marchi S, Giorgi C, Suski J, Agnoletto C, Bononi A, Bonora M . Mitochondria-ros crosstalk in the control of cell death and aging. J Signal Transduct. 2011; 2012:329635. PMC: 3235816. DOI: 10.1155/2012/329635. View

10.

Stevenson J . A woman's journey through the reproductive, transitional and postmenopausal periods of life: impact on cardiovascular and musculo-skeletal risk and the role of estrogen replacement. Maturitas. 2011; 70(2):197-205. DOI: 10.1016/j.maturitas.2011.05.017. View

11.

Tong Y, Li F, Lu Y, Cao Y, Gao J, Liu J . Rapamycin-sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary. Mol Reprod Dev. 2013; 80(12):1018-34. DOI: 10.1002/mrd.22267. View

12.

Fouany M, Sharara F . Is there a role for DHEA supplementation in women with diminished ovarian reserve?. J Assist Reprod Genet. 2013; 30(9):1239-44. PMC: 3800538. DOI: 10.1007/s10815-013-0018-x. View

13.

Kavutcu M, Canbolat O, Ozturk S, Olcay E, Ulutepe S, Ekinci C . Reduced enzymatic antioxidant defense mechanism in kidney tissues from gentamicin-treated guinea pigs: effects of vitamins E and C. Nephron. 1996; 72(2):269-74. DOI: 10.1159/000188853. View

14.

Zhu L, Li J, Xing N, Han D, Kuang H, Ge P . American ginseng regulates gene expression to protect against premature ovarian failure in rats. Biomed Res Int. 2015; 2015:767124. PMC: 4330957. DOI: 10.1155/2015/767124. View

15.

Lerner-Geva L, Rabinovici J, Lunenfeld B . Ovarian stimulation: is there a long-term risk for ovarian, breast and endometrial cancer?. Womens Health (Lond). 2010; 6(6):831-9. DOI: 10.2217/whe.10.67. View

16.

Gupta S, Patchva S, Koh W, Aggarwal B . Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2011; 39(3):283-99. PMC: 3288651. DOI: 10.1111/j.1440-1681.2011.05648.x. View

17.

Song K, Ma W, Huang C, Ding J, Cui D, Tan X . Effect and mechanism of Bushen Huoxue recipe on ovarian reserve in mice with premature ovarian failure. J Huazhong Univ Sci Technolog Med Sci. 2016; 36(4):571-575. DOI: 10.1007/s11596-016-1627-2. View

18.

Dragojevic-Dikic S, Marisavljevic D, Mitrovic A, Dikic S, Jovanovic T, Jankovic-Raznatovic S . An immunological insight into premature ovarian failure (POF). Autoimmun Rev. 2010; 9(11):771-4. DOI: 10.1016/j.autrev.2010.06.008. View

19.

Xu X, Chen X, Zhang X, Liu Y, Wang Z, Wang P . Impaired telomere length and telomerase activity in peripheral blood leukocytes and granulosa cells in patients with biochemical primary ovarian insufficiency. Hum Reprod. 2016; 32(1):201-207. DOI: 10.1093/humrep/dew283. View

20.

Aydos S, Elhan A, Tukun A . Is telomere length one of the determinants of reproductive life span?. Arch Gynecol Obstet. 2005; 272(2):113-6. DOI: 10.1007/s00404-004-0690-2. View