Low-Molecular-Weight Gelators As Base Materials for Ointments

Overview

Journal Gels

Date 2019 Jan 25

PMID 30674145

Citations 13

Authors

Yutaka Ohsedo

Affiliations

Soon will be listed here.

Abstract

Ointments have been widely used as an efficient means of transdermal drug application for centuries. In order to create ointments suitable for various new medicinal drugs, the creation of ointment base materials, such as gels, has attracted much research attention in this decade. On the other hand, the chemical tuning of low-molecular-weight gelators (LMWGs) has been increasingly studied for two decades because LMWGs can be tailored for different purposes by molecular design and modification. In this review, several series of studies related to the creation of ointment base materials with enhanced properties using existing and newly-created LMWGs are summarized.

Citing Articles

Chemiluminescent Reaction Induced by Mixing of Fluorescent-Dye-Containing Molecular Organogels with Aqueous Oxidant Solutions.

Ohsedo Y, Miyata K Gels. 2024; 10(8).

PMID: 39195021 PMC: 11353768. DOI: 10.3390/gels10080492.

Harnessing Glycolipids for Supramolecular Gelation: A Contemporary Review.

Holey S, Nayak R ACS Omega. 2024; 9(24):25513-25538.

PMID: 38911776 PMC: 11190938. DOI: 10.1021/acsomega.4c00958.

Creation of Molecular Gel Materials Using Polyrotaxane-Derived Polymeric Organogelator.

Ohsedo Y, Shinoda T Gels. 2023; 9(9).

PMID: 37754411 PMC: 10529233. DOI: 10.3390/gels9090730.

Development of Thixotropic Molecular Oleogels Comprising Alkylanilide Gelators by Using a Mixing Strategy.

Ohsedo Y Gels. 2023; 9(9).

PMID: 37754398 PMC: 10529973. DOI: 10.3390/gels9090717.

Creation of Polymer Hydrogelator/Poly(Vinyl Alcohol) Composite Molecular Hydrogel Materials.

Ohsedo Y, Ueno W Gels. 2023; 9(9).

PMID: 37754361 PMC: 10528823. DOI: 10.3390/gels9090679.

References

Dufresne M, Marouf E, Kranzlin Y, Gauthier M, Leroux J . Lipase is essential for the study of in vitro release kinetics from organogels. Mol Pharm. 2012; 9(6):1803-11. DOI: 10.1021/mp3001099. View

Babu S, Praveen V, Ajayaghosh A . Functional π-gelators and their applications. Chem Rev. 2014; 114(4):1973-2129. DOI: 10.1021/cr400195e. View

Boekhoven J, Stupp S . 25th anniversary article: supramolecular materials for regenerative medicine. Adv Mater. 2014; 26(11):1642-59. PMC: 4015801. DOI: 10.1002/adma.201304606. View

Okesola B, Vieira V, Cornwell D, Whitelaw N, Smith D . 1,3:2,4-Dibenzylidene-D-sorbitol (DBS) and its derivatives--efficient, versatile and industrially-relevant low-molecular-weight gelators with over 100 years of history and a bright future. Soft Matter. 2015; 11(24):4768-87. DOI: 10.1039/c5sm00845j. View

Zurcher D, McNeil A . Tools for identifying gelator scaffolds and solvents. J Org Chem. 2015; 80(5):2473-8. DOI: 10.1021/jo502915w. View

Ajay Mallia V, George M, Blair D, Weiss R . Robust organogels from nitrogen-containing derivatives of (R)-12-hydroxystearic acid as gelators: comparisons with gels from stearic acid derivatives. Langmuir. 2009; 25(15):8615-25. DOI: 10.1021/la8042439. View

Franz T . Percutaneous absorption on the relevance of in vitro data. J Invest Dermatol. 1975; 64(3):190-5. DOI: 10.1111/1523-1747.ep12533356. View

Lan Y, Corradini M, Weiss R, Raghavan S, Rogers M . To gel or not to gel: correlating molecular gelation with solvent parameters. Chem Soc Rev. 2015; 44(17):6035-58. DOI: 10.1039/c5cs00136f. View

Kumar D, Steed J . Supramolecular gel phase crystallization: orthogonal self-assembly under non-equilibrium conditions. Chem Soc Rev. 2013; 43(7):2080-8. DOI: 10.1039/c3cs60224a. View

10.

Sun Z, Li Z, He Y, Shen R, Deng L, Yang M . Ferrocenoyl phenylalanine: a new strategy toward supramolecular hydrogels with multistimuli responsive properties. J Am Chem Soc. 2013; 135(36):13379-86. DOI: 10.1021/ja403345p. View

11.

Penzes T, Blazso G, Aigner Z, Falkay G, Eros I . Topical absorption of piroxicam from organogels--in vitro and in vivo correlations. Int J Pharm. 2005; 298(1):47-54. DOI: 10.1016/j.ijpharm.2005.03.013. View

12.

Hoshizawa H, Minemura Y, Yoshikawa K, Suzuki M, Hanabusa K . Thixotropic hydrogelators based on a cyclo(dipeptide) derivative. Langmuir. 2013; 29(47):14666-73. DOI: 10.1021/la402333h. View

13.

Weiss R . The past, present, and future of molecular gels. What is the status of the field, and where is it going?. J Am Chem Soc. 2014; 136(21):7519-30. DOI: 10.1021/ja503363v. View

14.

Grassi M, Grassi G . Mathematical modelling and controlled drug delivery: matrix systems. Curr Drug Deliv. 2005; 2(1):97-116. DOI: 10.2174/1567201052772906. View

15.

Yu X, Chen L, Zhang M, Yi T . Low-molecular-mass gels responding to ultrasound and mechanical stress: towards self-healing materials. Chem Soc Rev. 2014; 43(15):5346-71. DOI: 10.1039/c4cs00066h. View

16.

Rest C, Kandanelli R, Fernandez G . Strategies to create hierarchical self-assembled structures via cooperative non-covalent interactions. Chem Soc Rev. 2015; 44(8):2543-72. DOI: 10.1039/c4cs00497c. View

17.

Bastiat G, Plourde F, Motulsky A, Furtos A, Dumont Y, Quirion R . Tyrosine-based rivastigmine-loaded organogels in the treatment of Alzheimer's disease. Biomaterials. 2010; 31(23):6031-8. PMC: 4807125. DOI: 10.1016/j.biomaterials.2010.04.009. View

18.

Howe E, Okesola B, Smith D . Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients. Chem Commun (Camb). 2015; 51(35):7451-4. DOI: 10.1039/c5cc01868d. View

19.

Sobczuk A, Tsuchiya Y, Shiraki T, Tamaru S, Shinkai S . Creation of chiral thixotropic gels through a crown-ammonium interaction and their application to a memory-erasing recycle system. Chemistry. 2012; 18(10):2832-8. DOI: 10.1002/chem.201103249. View

20.

Higuchi T . Rate of release of medicaments from ointment bases containing drugs in suspension. J Pharm Sci. 1961; 50:874-5. DOI: 10.1002/jps.2600501018. View