A Novel Histopathological Scoring System for Patients with Oral Squamous Cell Carcinoma

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2019 Jan 24

PMID 30673863

Citations 6

Authors

Ali-Farid Safi

Kathrin Grochau

Uta Drebber

Volker Schick

Oliver Thiele

Tim Backhaus

Hans-Joachim Nickenig

Joachim E Zoller

Matthias Kreppel

Affiliations

Soon will be listed here.

Abstract

Objectives: Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated to assess the biological aggressiveness of oral squamous cell carcinoma (OSCC). We aim to assess the prognostic impact of a novel scoring system, based upon the aforementioned histological parameters.

Materials And Methods: Retrospective chart review of 334 patients with treatment-naive squamous cell carcinoma of the oral cavity. Statistical analysis was performed using univariate and multivariate analysis. Histological grade G1 or G2 were assigned 0 points and G3 or G4 1 point. Invasion of the lymphatic vessels, blood vessels, or perineural space was given 1 point. Zero points were given, when invasion was not detectable. The final score was conducted through addition of each parameter. Therefore, our scoring system ranged between 0 and 4 points.

Results: T-classification (p < 0.001), N-classification (p < 0.001), UICC stage (p < 0.001), extracapsular spread (p < 0.001), locoregional recurrence (p < 0.001), and overall survival (p < 0.001) were significantly associated with the OSCC-Histoscore. In multivariate analysis, T-classification (p = 0.001), N-classification (p = 0.039), resection margins (p = 0.038), and OSCC-Histoscore (p < 0.001) were independent prognostic markers for overall survival rate.

Conclusion: Our presented OSCC-Histoscore serves as a strong independent prognostic parameter for 5-year overall survival (OS) and predicts OS better than T-classification, N-classification, and resection margins.

Clinical Relevance: Our presented histoscore improves prediction of the overall survival of patients with OSCC.

Citing Articles

Integrating lipid metabolite analysis with MRI-based transformer and radiomics for early and late stage prediction of oral squamous cell carcinoma.

Li W, Li Y, Gao S, Huang N, Kojima I, Kusama T BMC Cancer. 2024; 24(1):795.

PMID: 38961418 PMC: 11221018. DOI: 10.1186/s12885-024-12533-x.

Perineural Invasion Is a Significant Prognostic Factor in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Binmadi N, Alsharif M, Almazrooa S, Aljohani S, Akeel S, Osailan S Diagnostics (Basel). 2023; 13(21).

PMID: 37958235 PMC: 10649820. DOI: 10.3390/diagnostics13213339.

Preoperative Prediction of the Aggressiveness of Oral Tongue Squamous Cell Carcinoma with Quantitative Parameters from Dual-Energy Computed Tomography.

Yang X, Hu H, Zhang F, Li D, Yang Z, Shi G Front Oncol. 2022; 12:904471.

PMID: 35814448 PMC: 9260668. DOI: 10.3389/fonc.2022.904471.

Prognostic impact of perineural invasion in oral cancer: a systematic review.

Quintana D, Dedivitis R, Kowalski L Acta Otorhinolaryngol Ital. 2022; 42(1):17-25.

PMID: 35292785 PMC: 9058930. DOI: 10.14639/0392-100X-N1653.

Circular RNA circFOXO3 regulates KDM2A by targeting miR-214 to promote tumor growth and metastasis in oral squamous cell carcinoma.

Ai Y, Wu S, Zou C, Wei H J Cell Mol Med. 2021; 26(6):1842-1852.

PMID: 34117688 PMC: 8918406. DOI: 10.1111/jcmm.16533.

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