Mouse Cre-LoxP System: General Principles to Determine Tissue-specific Roles of Target Genes

Overview

Journal Lab Anim Res

Date 2019 Jan 24

PMID 30671100

Citations 148

Authors

Hyeonhui Kim

Minki Kim

Sun-Kyoung Im

Sungsoon Fang

Affiliations

Soon will be listed here.

Abstract

Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre- system is widely used as an integral experimental tool for generating the conditional. This system has enabled researchers to investigate genes of interest in a tissue/cell (spatial control) and/or time (temporal control) specific manner. A various tissue-specific Cre-driver mouse lines have been generated to date, and new Cre lines are still being developed. This review provides a brief overview of Cre- system and a few commonly used promoters for expression of tissue-specific Cre recombinase. Also, we finally introduce some available links to the Web sites that provides detailed information about Cre mouse lines including their characterization.

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