Oxidative Stress and Nutraceuticals in the Modulation of the Immune Function: Current Knowledge in Animals of Veterinary Interest

Overview

Journal Antioxidants (Basel)

Date 2019 Jan 24

PMID 30669304

Citations 29

Authors

Monica Colitti

Bruno Stefanon

Gianfranco Gabai

Maria Elena Gelain

Federico Bonsembiante

Affiliations

Soon will be listed here.

Abstract

In the veterinary sector, many papers deal with the relationships between inflammation and oxidative stress. However, few studies investigate the mechanisms of action of oxidised molecules in the regulation of immune cells. Thus, authors often assume that these events, sometime leading to oxidative stress, are conserved among species. The aim of this review is to draw the state-of-the-art of the current knowledge about the role of oxidised molecules and dietary antioxidant compounds in the regulation of the immune cell functions and suggest some perspectives for future investigations in animals of veterinary interest.

Citing Articles

Malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in canine serum: establishing reference intervals and influencing factors.

Perez-Montero B, Fermin-Rodriguez M, Portero-Fuentes M, Sarquis J, Caceres S, Portal J BMC Vet Res. 2025; 21(1):161.

PMID: 40069799 PMC: 11900598. DOI: 10.1186/s12917-025-04614-1.

Adaptation in the Alleyways: Candidate Genes Under Potential Selection in Urban Coyotes.

Kreling S, Vance S, Carlen E Genome Biol Evol. 2025; 17(1).

PMID: 39786569 PMC: 11775663. DOI: 10.1093/gbe/evae279.

Oxidative Stress in Canine Diseases: A Comprehensive Review.

Blanca P, Maria Luisa F, Guadalupe M, Fatima C Antioxidants (Basel). 2024; 13(11).

PMID: 39594538 PMC: 11591346. DOI: 10.3390/antiox13111396.

Serum total antioxidant status in dogs: Reference intervals and influence of multiple biological and analytical factors.

Perez-Montero B, Fermin-Rodriguez M, Portero-Fuentes M, Sarquis J, Caceres S, Portal J Vet Clin Pathol. 2024; 53(4):399-408.

PMID: 39396933 PMC: 11735657. DOI: 10.1111/vcp.13381.

Oxidative stress in poultry production.

Oke O, Akosile O, Oni A, Opowoye I, Ishola C, Adebiyi J Poult Sci. 2024; 103(9):104003.

PMID: 39084145 PMC: 11341942. DOI: 10.1016/j.psj.2024.104003.

References

Maddox J, Aherne K, Reddy C, Sordillo L . Increased neutrophil adherence and adhesion molecule mRNA expression in endothelial cells during selenium deficiency. J Leukoc Biol. 1999; 65(5):658-64. DOI: 10.1002/jlb.65.5.658. View

Wenisch C, Patruta S, Daxbock F, Krause R, Horl W . Effect of age on human neutrophil function. J Leukoc Biol. 2000; 67(1):40-5. DOI: 10.1002/jlb.67.1.40. View

Franceschi C, Bonafe M, Valensin S . Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine. 2000; 18(16):1717-20. DOI: 10.1016/s0264-410x(99)00513-7. View

Lavrovsky Y, Chatterjee B, Clark R, Roy A . Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol. 2000; 35(5):521-32. DOI: 10.1016/s0531-5565(00)00118-2. View

Medzhitov R, Janeway Jr C . Decoding the patterns of self and nonself by the innate immune system. Science. 2002; 296(5566):298-300. DOI: 10.1126/science.1068883. View

Head E, Liu J, Hagen T, Muggenburg B, Milgram N, Ames B . Oxidative damage increases with age in a canine model of human brain aging. J Neurochem. 2002; 82(2):375-81. DOI: 10.1046/j.1471-4159.2002.00969.x. View

Keaney Jr J, Larson M, Vasan R, Wilson P, Lipinska I, Corey D . Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol. 2003; 23(3):434-9. DOI: 10.1161/01.ATV.0000058402.34138.11. View

Jergens A, Schreiner C, Frank D, Niyo Y, Ahrens F, Eckersall P . A scoring index for disease activity in canine inflammatory bowel disease. J Vet Intern Med. 2003; 17(3):291-7. DOI: 10.1111/j.1939-1676.2003.tb02450.x. View

Zanni F, Vescovini R, Biasini C, Fagnoni F, Zanlari L, Telera A . Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp Gerontol. 2003; 38(9):981-7. DOI: 10.1016/s0531-5565(03)00160-8. View

10.

Stenlof K, Wernstedt I, Fjallman T, Wallenius V, Wallenius K, Jansson J . Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects. J Clin Endocrinol Metab. 2003; 88(9):4379-83. DOI: 10.1210/jc.2002-021733. View

11.

Surh Y . Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 2003; 3(10):768-80. DOI: 10.1038/nrc1189. View

12.

Boehmer E, Goral J, Faunce D, Kovacs E . Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol. 2003; 75(2):342-9. DOI: 10.1189/jlb.0803389. View

13.

Vertuani S, Angusti A, Manfredini S . The antioxidants and pro-antioxidants network: an overview. Curr Pharm Des. 2004; 10(14):1677-94. DOI: 10.2174/1381612043384655. View

14.

Grundy S . What is the contribution of obesity to the metabolic syndrome?. Endocrinol Metab Clin North Am. 2004; 33(2):267-82, table of contents. DOI: 10.1016/j.ecl.2004.03.001. View

15.

Kobayashi A, Kang M, Okawa H, Ohtsuji M, Zenke Y, Chiba T . Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol. 2004; 24(16):7130-9. PMC: 479737. DOI: 10.1128/MCB.24.16.7130-7139.2004. View

16.

Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y . Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004; 114(12):1752-61. PMC: 535065. DOI: 10.1172/JCI21625. View

17.

de la Fuente M, Hernanz A, Guayerbas N, Alvarez P, Alvarado C . Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence. Cell Mol Biol (Noisy-le-grand). 2004; 50 Online Pub:OL683-90. View

18.

Larbi A, Dupuis G, Douziech N, Khalil A, Fulop Jr T . Low-grade inflammation with aging has consequences for T-lymphocyte signaling. Ann N Y Acad Sci. 2005; 1030:125-33. DOI: 10.1196/annals.1329.016. View

19.

Acamovic T, Brooker J . Biochemistry of plant secondary metabolites and their effects in animals. Proc Nutr Soc. 2005; 64(3):403-12. DOI: 10.1079/pns2005449. View

20.

Stefanon B, Sgorlon S, Gabai G . Usefulness of nutraceutics in controlling oxidative stress in dairy cows around parturition. Vet Res Commun. 2005; 29 Suppl 2:387-90. DOI: 10.1007/s11259-005-0088-z. View