β-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But Not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies

Overview

Journal Genet Test Mol Biomarkers

Specialties Genetics
Molecular Biology

Date 2019 Jan 23

PMID 30668166

Citations 5

Authors

Yanrong Li

Huiping Yuan

Liang Sun

Qi Zhou

Fan Yang

Ze Yang

Deping Liu

Affiliations

Soon will be listed here.

Abstract

Aims: β-Adrenergic receptors (ADRBs) play a pivotal role in cardiovascular disease. Recently, genetic polymorphisms of ADRB1 and ADRB2 have been suggested to be associated with cardiovascular events and all-cause mortality in coronary artery disease (CAD) patients, but the results of relevant studies are inconsistent and controversial. Therefore, we performed a meta-analysis to investigate the association between ADRB1 and ADRB2 polymorphisms with cardiovascular events and all-cause mortality in CAD patients.

Materials And Methods: The PubMed, Ovid, EMBASE, Cochrane, and CINAHL databases were searched for eligible studies published before April 2018. A total of 5495 patients from eight studies were included in our meta-analysis.

Results: We found that CAD patients harboring the ADRB2 rs1042714 Glu27 allele exhibited a positive association with cardiovascular events (risk ratio [RR] = 1.31, 95% confidence interval [CI]: 1.08-1.58, p = 0.006), but not with all-cause mortality (RR = 0.97, 95% CI: 0.70-1.35, p = 0.859), compared with patients who were Gln27 homozygotes. No other significant associations were observed between ADRB1 (rs1801252, rs1801253), ADRB2 (rs1042713, rs1800888) polymorphisms and cardiovascular events or all-cause mortality in CAD patients.

Conclusion: This study suggests that the identified ADRB2 polymorphism could influence the outcomes of CAD patients, showing important clinical value.

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