Evaluation of Hypertriglyceridemia-induced Acute Pancreatitis: A Single Tertiary Care Unit Experience from Turkey

Overview

Journal Turk J Gastroenterol

Publisher Aves

Specialty Gastroenterology

Date 2019 Jan 23

PMID 30666968

Citations 7

Authors

Orhan Sezgin

Osman Ozdogan

Serkan Yaras

Enver Ucbilek

Engin Altintas

Affiliations

Soon will be listed here.

Abstract

Background/aims: This study aimed to determine the frequency of hypertriglyceridemia (HTG)-induced acute pancreatitis (AP) and assess different clinical and prognostic features in these patients.

Materials And Methods: The patients who were hospitalized with AP due to HTG (HTG-AP) between January 2005 and December 2014 were retrospectively evaluated in the clinic. The patients with AP due to non-HTG (non-HTG-AP) were also investigated during the same period.

Results: Of 635 patients with AP admitted to the clinic, 33 (5.2%) had HTG-related AP. Mean triglyceride levels were 2653 mg/dL (range: 439-13700 mg/dL). Mean Ranson score at the time of admission was 1.5, and the APACHE II score was 4.63. The mean duration of hospitalization was 4.4 days (range: 2-14 days). One of these patients died on the sixth day of hospitalization due to multiple-organ failure. Patients with a triglyceride level of >1000 mg/dL were younger, had a longer hospital stay, and had a higher recurrence rate. Compared with non-HTG-AP, HTG-AP was observed at a younger age (57.4±17.3 vs. 37.6±14.8, p<0.05, respectively) and more frequently in males (45.2% vs. 57.6%, p<0.05, respectively). The frequency of multiple AP in patients with HTG-AP was higher than non-HTG-AP (63.4% vs. 7.6%, respectively).

Conclusion: HTG-AP was observed at a younger age and was responsible for most cases of recurrent pancreatitis. The duration of hospitalization was long, and the risk of recurrence and mortality were high in patients with HTG-AP having a triglyceride level >1000 mg/dL.

Citing Articles

Hypertriglyceridemia-Induced Acute Pancreatitis-The Milky Way Constellation-The Seven-Year Experience of a Large Tertiary Centre.

Edu A, Pahomeanu M, Ghita A, Constantinescu D, Grigore D, Bota A Diagnostics (Basel). 2024; 14(11).

PMID: 38893632 PMC: 11172297. DOI: 10.3390/diagnostics14111105.

A nomogram for predicting in-hospital overall survival of hypertriglyceridemia-induced severe acute pancreatitis: A single center, cross-sectional study.

Wu H, Liao B, Ji T, Jia S, Luo Y, Ma K Heliyon. 2024; 10(1):e23454.

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COVID-19 treatment: A potential cause of acute pancreatitis.

Allam M, El-Zawawy H, Ahmed S, Abdelhamid M Clin Case Rep. 2022; 10(10):e6465.

PMID: 36285030 PMC: 9585043. DOI: 10.1002/ccr3.6465.

The role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study.

Yang X, He J, Ma S, Wang T, Zhu Q, Cao F Lipids Health Dis. 2021; 20(1):171.

PMID: 34838056 PMC: 8627607. DOI: 10.1186/s12944-021-01597-4.

Hypertriglyceridemia Acute Pancreatitis: Animal Experiment Research.

Wang L, Xu T, Wang R, Wang X, Wu D Dig Dis Sci. 2021; 67(3):761-772.

PMID: 33939144 DOI: 10.1007/s10620-021-06928-0.

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