Iron Oxide Nanoparticles Promote the Migration of Mesenchymal Stem Cells to Injury Sites

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2019 Jan 23

PMID 30666115

Citations 32

Authors

Xiuying Li

Zhenhong Wei

Huiying Lv

Liya Wu

Yingnan Cui

Hua Yao

Jing Li

Hao Zhang

Bai Yang

Jinlan Jiang

Affiliations

Soon will be listed here.

Abstract

Background: Developing new methods to deliver cells to the injured tissue is a critical factor in translating cell therapeutics research into clinical use; therefore, there is a need for improved cell homing capabilities.

Materials And Methods: In this study, we demonstrated the effects of labeling rat bone marrow-derived mesenchymal stem cells (MSCs) with fabricated polydopamine (PDA)-capped FeO (FeO@PDA) superparticles employing preassembled FeO nanoparticles as the cores.

Results: We found that the FeO@PDA composite superparticles exhibited no adverse effects on MSC characteristics. Moreover, iron oxide nanoparticles increased the number of MSCs in the S-phase, their proliferation index and migration ability, and their secretion of vascular endothelial growth factor relative to unlabeled MSCs. Interestingly, nanoparticles not only promoted the expression of C-X-C chemokine receptor 4 but also increased the expression of the migration-related proteins c-Met and C-C motif chemokine receptor 1, which has not been reported previously. Furthermore, the MSC-loaded nanoparticles exhibited improved homing and anti-inflammatory abilities in the absence of external magnetic fields in vivo.

Conclusion: These results indicated that iron oxide nanoparticles rendered MSCs more favorable for use in injury treatment with no negative effects on MSC properties, suggesting their potential clinical efficacy.

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