Vitamin D and Probiotic Co-supplementation Affects Mental Health, Hormonal, Inflammatory and Oxidative Stress Parameters in Women with Polycystic Ovary Syndrome

Overview

Journal J Ovarian Res

Publisher Biomed Central

Specialties Gynecology & Obstetrics
Reproductive Medicine

Date 2019 Jan 23

PMID 30665436

Citations 55

Authors

Vahidreza Ostadmohammadi

Mehri Jamilian

Fereshteh Bahmani

Zatollah Asemi

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS).

Methods: This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18-40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 10 CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks.

Results: Vitamin D and probiotic co-supplementation, compared with the placebo, significantly improved beck depression inventory [β (difference in the mean of outcomes measures between treatment groups) - 0.58; 95% CI, - 1.15, - 0.02; P = 0.04], general health questionnaire scores (β - 0.93; 95% CI, - 1.78, - 0.08; P = 0.03) and depression, anxiety and stress scale scores (β - 0.90; 95% CI, - 1.67, - 0.13; P = 0.02). Vitamin D and probiotic co-supplementation was associated with a significant reduction in total testosterone (β - 0.19 ng/mL; 95% CI, - 0.28, - 0.10; P < 0.001), hirsutism (β - 0.95; 95% CI, - 1.39, - 0.51; P < 0.001), high-sensitivity C-reactive protein (hs-CRP) (β - 0.67 mg/L; 95% CI, - 0.97, - 0.38; P < 0.001) and malondialdehyde (MDA) levels (β - 0.25 μmol/L; 95% CI, - 0.40, - 0.10; P = 0.001), and a significant increase in total antioxidant capacity (TAC) (β 82.81 mmol/L; 95% CI, 42.86, 122.75; P < 0.001) and total glutathione (GSH) levels (β 40.42 μmol/L; 95% CI, 4.69, 76.19; P = 0.02), compared with the placebo.

Conclusions: Overall, the co-administration of vitamin D and probiotic for 12 weeks to women with PCOS had beneficial effects on mental health parameters, serum total testosterone, hirsutism, hs-CRP, plasma TAC, GSH and MDA levels.

Trial Registration: This study was retrospectively registered in the Iranian website ( www.irct.ir ) for registration of clinical trials ( IRCT20170513033941N37 ).

Citing Articles

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Effects of a Novel Fortified Dairy Product on the Psychological Status and Sleep Quality of Patients with Polycystic Ovary Syndrome: A Double-Blind Randomized Controlled Trial.

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Exploring the causal associations of the gut microbiota and plasma metabolites with ovarian cancer: an approach of mendelian randomization analysis combined with network pharmacology and molecular docking.

Guo J, Wang C, Li H, Ding C J Ovarian Res. 2025; 18(1):27.

PMID: 39948579 PMC: 11823090. DOI: 10.1186/s13048-025-01610-9.

The Role of Lifestyle Interventions in PCOS Management: A Systematic Review.

Gautam R, Maan P, Jyoti A, Kumar A, Malhotra N, Arora T Nutrients. 2025; 17(2).

PMID: 39861440 PMC: 11767734. DOI: 10.3390/nu17020310.

Research trend and hotspots of polycystic ovary syndrome with depression from 1993 to 2024: a bibliometric analysis.

Xie J, Cao Y, Wen Q, Song X, Shi Y, Gao X Front Glob Womens Health. 2024; 5:1468471.

PMID: 39669109 PMC: 11634872. DOI: 10.3389/fgwh.2024.1468471.

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