Feasibility of Intraocular Projection for Treatment of Intractable Corneal Opacity

Overview

Journal Cornea

Specialty Ophthalmology

Date 2019 Jan 22

PMID 30664047

Citations 8

Authors

Sarah Y Shim

Songbin Gong

Mark I Rosenblatt

Daniel Palanker

Ahmed Al-Qahtani

Michael G Sun

Qiang Zhou

Levi Kanu

Felix Chau

Charles Q Yu

Affiliations

Soon will be listed here.

Abstract

Despite many decades of research and development, corneal opacity remains a leading cause of reversible blindness worldwide. Corneal transplantation and keratoprosthesis can restore corneal clarity, but both have well-known limitations. High-resolution electronic microdisplays may offer an alternative to traditional methods of treating corneal disease using an intraocular implant to project imagery onto the retina, obviating the need for a clear cornea. In this study, we review previous work and recent technologic developments relevant to the development of such an intraocular projection system.

Citing Articles

A sustainable approach to derive sheep corneal scaffolds from stored slaughterhouse waste.

Ali Z, Wang X, Shibru M, Alhosani M, Alfadhli N, Alnuaimi A Regen Med. 2024; 19(6):303-315.

PMID: 39177571 PMC: 11346552. DOI: 10.1080/17460751.2024.2357499.

Axisymmetric Thermal Finite Element Analysis of Effects of Intraocular Projector in the Human Eye.

Stark J, Foster C, Yu C Am J Undergrad Res. 2023; 17(4):49-57.

PMID: 37636995 PMC: 10457096. DOI: 10.33697/ajur.2020.035.

Temperature Elevation in the Human Eye Due To Intraocular Projection Prosthesis Device.

Gongal D, Thakur S, Panse A, Stark J, Yu C, Foster C J Therm Sci Eng Appl. 2022; 13(6).

PMID: 36284522 PMC: 9592079. DOI: 10.1115/1.4050237.

THERMAL ANALYSIS OF INTRAOCULAR ELECTRONIC DISPLAY PROJECTOR VISUAL PROSTHESIS.

Gongal D, Thakur S, Panse A, Pawar R, Yu C, Foster C Numeri Heat Transf A Appl. 2021; 78(12):706-716.

PMID: 33776378 PMC: 7993088. DOI: 10.1080/10407782.2020.1805230.

Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract-based spatial statistics study.

Liu Y, Li B, Wu K, Tang L, Lin Q, Li Q Brain Behav. 2020; 10(8):e01720.

PMID: 32558355 PMC: 7428480. DOI: 10.1002/brb3.1720.

References

Islam S, Doyle E, Velilla A, Martin C, Ducatman A . Epidemiology of compensable work-related ocular injuries and illnesses: incidence and risk factors. J Occup Environ Med. 2000; 42(6):575-81. DOI: 10.1097/00043764-200006000-00004. View

Stork W, Eix I . Micro displays as intraocular vision aid--design of an optical system. Biomed Tech (Berl). 2002; 47 Suppl 1 Pt 1:161-3. DOI: 10.1515/bmte.2002.47.s1a.161. View

Puettjer D, Praemassing F, Buss R, Jaeger D . LED-display for an intraocular microoptic system. Biomed Tech (Berl). 2002; 47 Suppl 1 Pt 1:164-6. DOI: 10.1515/bmte.2002.47.s1a.164. View

Krisch I, Hijazi N, Hosticka B . Image acquisition and image processing for the intraocular vision aid. Biomed Tech (Berl). 2002; 47 Suppl 1 Pt 1:171-3. DOI: 10.1515/bmte.2002.47.s1a.171. View

Hijazi N, Krisch I, Hosticka B . Wireless power and data transmission system for a micro implantable intraocular vision aid. Biomed Tech (Berl). 2002; 47 Suppl 1 Pt 1:174-5. DOI: 10.1515/bmte.2002.47.s1a.174. View

Spencer R . Change in weight of the human lens with age. Ann Ophthalmol. 1976; 8(4):440-1. View

Bartels M, Doxiadis I, Colen T, Beekhuis W . Long-term outcome in high-risk corneal transplantation and the influence of HLA-A and HLA-B matching. Cornea. 2003; 22(6):552-6. DOI: 10.1097/00003226-200308000-00013. View

Szurman P, Warga M, Roters S, Grisanti S, Heimann U, Aisenbrey S . Experimental implantation and long-term testing of an intraocular vision aid in rabbits. Arch Ophthalmol. 2005; 123(7):964-9. DOI: 10.1001/archopht.123.7.964. View

Lazzi G . Thermal effects of bioimplants. IEEE Eng Med Biol Mag. 2005; 24(5):75-81. DOI: 10.1109/memb.2005.1511503. View

10.

Higgins G, Allan R, Hall R, Field E, Kaye S . Development of ocular disease in patients with mucous membrane pemphigoid involving the oral mucosa. Br J Ophthalmol. 2006; 90(8):964-7. PMC: 1857184. DOI: 10.1136/bjo.2006.092528. View

11.

Tsai J, Derby E, Holland E, Khatana A . Incidence and prevalence of glaucoma in severe ocular surface disease. Cornea. 2006; 25(5):530-2. DOI: 10.1097/01.ico.0000220776.93852.d9. View

12.

Colby K, Chang D, Stulting R, Lane S . Surgical placement of an optical prosthetic device for end-stage macular degeneration: the implantable miniature telescope. Arch Ophthalmol. 2007; 125(8):1118-21. DOI: 10.1001/archopht.125.8.1118. View

13.

Dubra A, Sulai Y, Norris J, Cooper R, Dubis A, Williams D . Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope. Biomed Opt Express. 2011; 2(7):1864-76. PMC: 3130574. DOI: 10.1364/BOE.2.001864. View

14.

Opie N, Burkitt A, Meffin H, Grayden D . Heating of the eye by a retinal prosthesis: modeling, cadaver and in vivo study. IEEE Trans Biomed Eng. 2011; 59(2):339-45. DOI: 10.1109/TBME.2011.2171961. View

15.

Humayun M, Dorn J, da Cruz L, Dagnelie G, Sahel J, Stanga P . Interim results from the international trial of Second Sight's visual prosthesis. Ophthalmology. 2012; 119(4):779-88. PMC: 3319859. DOI: 10.1016/j.ophtha.2011.09.028. View

16.

Opie N, Greferath U, Vessey K, Burkitt A, Meffin H, Grayden D . Retinal prosthesis safety: alterations in microglia morphology due to thermal damage and retinal implant contact. Invest Ophthalmol Vis Sci. 2012; 53(12):7802-12. DOI: 10.1167/iovs.12-10600. View

17.

Yamane S, Inoue M, Arakawa A, Kadonosono K . Sutureless 27-gauge needle-guided intrascleral intraocular lens implantation with lamellar scleral dissection. Ophthalmology. 2013; 121(1):61-66. DOI: 10.1016/j.ophtha.2013.08.043. View

18.

Stronks H, Dagnelie G . The functional performance of the Argus II retinal prosthesis. Expert Rev Med Devices. 2013; 11(1):23-30. PMC: 3926652. DOI: 10.1586/17434440.2014.862494. View

19.

Stingl K, Bartz-Schmidt K, Besch D, Chee C, Cottriall C, Gekeler F . Subretinal Visual Implant Alpha IMS--Clinical trial interim report. Vision Res. 2015; 111(Pt B):149-60. DOI: 10.1016/j.visres.2015.03.001. View

20.

Lorach H, Goetz G, Smith R, Lei X, Mandel Y, Kamins T . Photovoltaic restoration of sight with high visual acuity. Nat Med. 2015; 21(5):476-82. PMC: 4601644. DOI: 10.1038/nm.3851. View