Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease

Overview

Journal Stroke

Specialties Cardiology & Vascular Diseases
Neurology

Date 2019 Jan 22

PMID 30661504

Citations 15

Authors

Kristin P Guilliams

Melanie E Fields

Michael M Dowling

Affiliations

Soon will be listed here.

Citing Articles

Cerebral Oxygen Metabolic Stress in Children and Adults With Large Vessel Vasculopathy Due to Sickle Cell Disease.

Wang Y, Fellah S, Reis M, Guilliams K, Fields M, Steger-May K Neurology. 2024; 103(11):e210032.

PMID: 39546738 PMC: 11573263. DOI: 10.1212/WNL.0000000000210032.

Changes in indicators of cerebral metabolic stress following treatment with voxelotor in children and adolescents with sickle cell anemia.

Heitzer A, Zou P, Hodges J, Brown C, Davis M, Dixon S EJHaem. 2024; 5(5):976-980.

PMID: 39415936 PMC: 11474350. DOI: 10.1002/jha2.1001.

Stroke without cerebral arteriopathy in sickle cell disease children: causes and treatment.

Linguet S, Verlhac S, Missud F, Holvoet-Vermaut L, Brousse V, Ithier G Haematologica. 2024; 109(10):3346-3356.

PMID: 38497171 PMC: 11443367. DOI: 10.3324/haematol.2023.283773.

Multi-center retrospective study of children with sickle cell disease admitted to pediatric intensive care units in the United States.

Ettinger N, Guffey D, Anum S, Fasipe T, Katkin J, Bhar S Sci Rep. 2023; 13(1):6758.

PMID: 37185357 PMC: 10130031. DOI: 10.1038/s41598-023-32651-z.

Association of laboratory markers and cerebral blood flow among sickle cell anemia children.

Adanho C, Yahouedehou S, Santana S, Vieira C, Santiago R, de Santana J Front Pediatr. 2022; 10:914466.

PMID: 36090571 PMC: 9458965. DOI: 10.3389/fped.2022.914466.

References

Rothman S, Fulling K, Nelson J . Sickle cell anemia and central nervous system infarction: a neuropathological study. Ann Neurol. 1986; 20(6):684-90. DOI: 10.1002/ana.410200606. View

Yang W, Xu R, Porras J, Takemoto C, Khalid S, Garzon-Muvdi T . Effectiveness of surgical revascularization for stroke prevention in pediatric patients with sickle cell disease and moyamoya syndrome. J Neurosurg Pediatr. 2017; 20(3):232-238. DOI: 10.3171/2017.1.PEDS16576. View

Dowling M, Quinn C, Ramaciotti C, Kanter J, Osunkwo I, Inusa B . Increased prevalence of potential right-to-left shunting in children with sickle cell anaemia and stroke. Br J Haematol. 2016; 176(2):300-308. PMC: 5239723. DOI: 10.1111/bjh.14391. View

Thangarajh M, Yang G, Fuchs D, Ponisio M, McKinstry R, Jaju A . Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia. Br J Haematol. 2012; 159(3):352-9. PMC: 3775590. DOI: 10.1111/bjh.12034. View

Miller S, Macklin E, Pegelow C, Kinney T, Sleeper L, Bello J . Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: a report from the Cooperative Study of Sickle Cell Disease. J Pediatr. 2001; 139(3):385-90. DOI: 10.1067/mpd.2001.117580. View

Lagunju I, Brown B, Sodeinde O . Hydroxyurea lowers transcranial Doppler flow velocities in children with sickle cell anaemia in a Nigerian cohort. Pediatr Blood Cancer. 2015; 62(9):1587-91. DOI: 10.1002/pbc.25529. View

Piel F, Patil A, Howes R, Nyangiri O, Gething P, Dewi M . Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates. Lancet. 2012; 381(9861):142-51. PMC: 3547249. DOI: 10.1016/S0140-6736(12)61229-X. View

Pegelow C, Adams R, McKie V, Abboud M, Berman B, Miller S . Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions. J Pediatr. 1995; 126(6):896-9. DOI: 10.1016/s0022-3476(95)70204-0. View

Powers W, Grubb Jr R, Darriet D, Raichle M . Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab. 1985; 5(4):600-8. DOI: 10.1038/jcbfm.1985.89. View

10.

Yawn B, Buchanan G, Afenyi-Annan A, Ballas S, Hassell K, James A . Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. JAMA. 2014; 312(10):1033-48. DOI: 10.1001/jama.2014.10517. View

11.

BECKLAKE M, Griffiths S, McGregor M, GOLDMAN H, SCHREVE J . Oxygen dissociation curves in sickle cell anemia and in subjects with the sickle cell trait. J Clin Invest. 1955; 34(5):751-5. PMC: 438687. DOI: 10.1172/JCI103129. View

12.

Behpour A, Shah P, Mikulis D, Kassner A . Cerebral blood flow abnormalities in children with sickle cell disease: a systematic review. Pediatr Neurol. 2013; 48(3):188-99. DOI: 10.1016/j.pediatrneurol.2012.12.004. View

13.

Griessenauer C, Lebensburger J, Chua M, Fisher 3rd W, Hilliard L, Bemrich-Stolz C . Encephaloduroarteriosynangiosis and encephalomyoarteriosynangiosis for treatment of moyamoya syndrome in pediatric patients with sickle cell disease. J Neurosurg Pediatr. 2015; 16(1):64-73. DOI: 10.3171/2014.12.PEDS14522. View

14.

Galadanci N, Abdullahi S, Vance L, Tabari A, Ali S, Belonwu R . Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial). Am J Hematol. 2017; 92(8):780-788. PMC: 5523858. DOI: 10.1002/ajh.24770. View

15.

Adams R, Brambilla D . Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease. N Engl J Med. 2005; 353(26):2769-78. DOI: 10.1056/NEJMoa050460. View

16.

Jordan L, Gindville M, Scott A, Juttukonda M, Strother M, Kassim A . Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia. Brain. 2016; 139(Pt 3):738-50. PMC: 5014126. DOI: 10.1093/brain/awv397. View

17.

Prohovnik I, Pavlakis S, Piomelli S, Bello J, Mohr J, Hilal S . Cerebral hyperemia, stroke, and transfusion in sickle cell disease. Neurology. 1989; 39(3):344-8. DOI: 10.1212/wnl.39.3.344. View

18.

Helton K, Adams R, Kesler K, Lockhart A, Aygun B, Driscoll C . Magnetic resonance imaging/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial. Blood. 2014; 124(6):891-8. PMC: 4126329. DOI: 10.1182/blood-2013-12-545186. View

19.

Kosinski P, Croal P, Leung J, Williams S, Odame I, Hare G . The severity of anaemia depletes cerebrovascular dilatory reserve in children with sickle cell disease: a quantitative magnetic resonance imaging study. Br J Haematol. 2016; 176(2):280-287. DOI: 10.1111/bjh.14424. View

20.

An H, Sen S, Chen Y, Powers W, Lin W . Noninvasive Measurements of Cerebral Blood Flow, Oxygen Extraction Fraction, and Oxygen Metabolic Index in Human with Inhalation of Air and Carbogen using Magnetic Resonance Imaging. Transl Stroke Res. 2013; 3(2):246-54. DOI: 10.1007/s12975-011-0142-9. View