» Articles » PMID: 30652072

Utility of GDF-15 As a Diagnostic Biomarker in Gastric Cancer: an Investigation Combining GEO, TCGA and Meta-analysis

Overview
Journal FEBS Open Bio
Specialty Biology
Date 2019 Jan 18
PMID 30652072
Citations 11
Authors
Affiliations
Soon will be listed here.
Abstract

It was recently suggested that growth differentiation factor-15 (GDF-15) is associated with gastric cancer (GC) carcinogenesis. However, the diagnostic potential of GDF-15 for GC remains unclear. To address this issue, we obtained RNA sequencing and microarray data from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases, and searched PubMed, Google Scholar and Web of Science for relevant literature. We then used STATA to perform a meta-analysis. In total, reports of 253 GC patients and 112 healthy controls who contributed peripheral blood samples were taken from the four literature sources, while information on 754 GC tumor and 263 gastric normal tissues was drawn from TCGA and seven GEO datasets. The expression level of mRNA was significantly higher in tumor tissues than in normal tissues, with a standard mean difference (SMD) of 0.79% and a 95% confidence interval (95% CI) of 0.63-0.95. Consistently, the GDF-15 protein in blood was significantly increased in GC patients as compared to controls (SMD = 3.74, 95% CI = 1.81-5.68). In addition, based on information from TCGA and GEO datasets, the expression level of mRNA may be of use for the diagnosis of GC, with a combined sensitivity, specificity and odds ratio of 0.69 (95% CI = 0.58-0.79), 0.90 (95% CI = 0.84-0.93) and 6.32 (95% CI = 4.22-9.49), respectively. The summary receiver operating characteristic curve demonstrated that the area under the curve was 0.90 (95% CI = 0.87-0.93). The results suggest higher levels of GDF-15 may be associated with GC tumorigenesis and may have the potential to be a diagnostic biomarker of GC.

Citing Articles

GDF15 Promotes Cell Growth, Migration, and Invasion in Gastric Cancer by Inducing STAT3 Activation.

Joo M, Kim D, Lee M, Lee H, Kim J Int J Mol Sci. 2023; 24(3).

PMID: 36769245 PMC: 9917887. DOI: 10.3390/ijms24032925.


ALDH2 promotes uterine corpus endometrial carcinoma proliferation and construction of clinical survival prognostic model.

Cui Y, Xiang Y, Meng F, Ji C, Xiao R, Li J Aging (Albany NY). 2021; 13(20):23588-23602.

PMID: 34670872 PMC: 8580334. DOI: 10.18632/aging.203605.


Deciphering the effects of PYCR1 on cell function and its associated mechanism in hepatocellular carcinoma.

Xu Y, Zuo W, Wang X, Zhang Q, Gan X, Tan N Int J Biol Sci. 2021; 17(9):2223-2239.

PMID: 34239351 PMC: 8241733. DOI: 10.7150/ijbs.58026.


The Association Among Serum Growth Differentiation Factor 15 Level and Suicidal Ideation is Dependent on Testosterone Deficiency in Depressive Patients.

Peng R, Li D, Mei S, Li Y J Inflamm Res. 2021; 14:2723-2730.

PMID: 34194235 PMC: 8238534. DOI: 10.2147/JIR.S313200.


Expression of the Body-Weight Signaling Players: GDF15, GFRAL and RET and their clinical relevance in Gastric Cancer.

Buchholz K, Antosik P, Grzanka D, Gagat M, Smolinska M, Grzanka A J Cancer. 2021; 12(15):4698-4709.

PMID: 34149933 PMC: 8210553. DOI: 10.7150/jca.55511.


References
1.
Karimi P, Islami F, Anandasabapathy S, Freedman N, Kamangar F . Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 2014; 23(5):700-13. PMC: 4019373. DOI: 10.1158/1055-9965.EPI-13-1057. View

2.
Li Q, Zhang J, Zhou Y, Qiao L . Obesity and gastric cancer. Front Biosci (Landmark Ed). 2012; 17(7):2383-90. DOI: 10.2741/4059. View

3.
Guo J, Bian Y, Wang Y, Chen L, Yu A, Sun X . S100A4 influences cancer stem cell-like properties of MGC803 gastric cancer cells by regulating GDF15 expression. Int J Oncol. 2016; 49(2):559-68. DOI: 10.3892/ijo.2016.3556. View

4.
Sun C, Yuan Q, Wu D, Meng X, Wang B . Identification of core genes and outcome in gastric cancer using bioinformatics analysis. Oncotarget. 2017; 8(41):70271-70280. PMC: 5642553. DOI: 10.18632/oncotarget.20082. View

5.
Brown D, Ward R, Buckhaults P, Liu T, Romans K, Hawkins N . MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. Clin Cancer Res. 2003; 9(7):2642-50. View