Correlation Analysis Between 25-hydroxyvitamin D3, Vitamin B12 and Vitamin C and Endothelial Function of Patients with CHD

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2019 Jan 18

PMID 30651815

Citations 3

Authors

Xiaoming Qin

Lei Qin

Jiachen Luo

Baoxin Liu

Jinlong Zhao

Hongqiang Li

Yidong Wei

Affiliations

Soon will be listed here.

Abstract

The aim of the study was to investigate the correlation between levels of 25-hydroxyvitamin D3, vitamin B12 and C and endothelial function of patients with coronary heart disease (CHD). Forty patients with CHD diagnosed in Shanghai Tenth People's Hospital from May 2016 to April 2017 were selected as the observation group. A total of 45 healthy individuals were selected as the control group. The participants included 54 males and 31 females. General information was collected. Peripheral serum biochemical indicators, levels of 25-hydroxyvitamin D3, vitamin B12 and C, homocysteine (Hcy), nitric oxide (NO) and endothelial NOS (eNOS) were measured. Arterial lesions detected by coronary angiography were recorded and indexes of observation and control group were compared for the correlation analysis. A proportion of hypertensive patients and their body mass index (BMI) were significantly higher in the observation than in the control group (P<0.05). Levels of 25-hydroxyvitamin D3, vitamin B12 and C in peripheral blood of observation were significantly lower than those of the control group (P<0.05). Compared with the control group, incidence of single-branch lesion and non-lesion rate were significantly lower, but incidence of double- and triple-branch lesions were significantly higher in observation than in control group (P<0.05). In addition, the level of Hcy in the observation group was higher than that in the control group, but levels of NO and eNOS in observation were significantly lower than those in control group (P<0.05. The correlation analysis revealed that 25-hydroxyvitamin D3 (r=0.792, P<0.01), vitamin B12 (r=0.635, P<0.01) and vitamin C (r=0.703, P<0.01) were negatively correlated with serum NO level. Thus, hypertension, BMI, 25-hydroxyvitamin D3, vitamin B12 and C have independent predictive value for coronary endothelial dysfunction (P<0.05). In conclusion, serum levels of 25-hydroxyvitamin D3, vitamin B12 and C are closely related to vascular endothelial dysfunction in patients with CHD and affect the severity of vascular endothelial dysfunction in patients with CHD.

Citing Articles

The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat.

Kazemimiraki M, Moazamian E, Mokhtari M, Gholamzad M Neuromolecular Med. 2025; 27(1):14.

PMID: 39961943 DOI: 10.1007/s12017-025-08837-1.

Association between homocysteine and blood pressure in the NHANES 2003-2006: the mediating role of Vitamin C.

Wu P, Ma J, Yang S, Wu H, Ma X, Chen D Front Nutr. 2024; 11:1379096.

PMID: 38765818 PMC: 11099269. DOI: 10.3389/fnut.2024.1379096.

Circulating Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 (sLOX-1): A Diagnostic Indicator across the Spectrum of Acute Coronary Syndrome.

Kumar S, Ali W, Mishra S, Pradhan A, Sethi R, Kushwaha R J Clin Med. 2021; 10(23).

PMID: 34884269 PMC: 8658522. DOI: 10.3390/jcm10235567.

Piwi-interacting RNAs play a role in vitamin C-mediated effects on endothelial aging.

Zheng S, Zheng H, Huang A, Mai L, Huang X, Hu Y Int J Med Sci. 2020; 17(7):946-952.

PMID: 32308548 PMC: 7163353. DOI: 10.7150/ijms.42586.

References

Vermeer S, den Heijer T, Koudstaal P, Oudkerk M, Hofman A, Breteler M . Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke. 2003; 34(2):392-6. DOI: 10.1161/01.str.0000052631.98405.15. View

Darius H, Pittrow D, Haberl R, Trampisch H, Schuster A, Lange S . Are elevated homocysteine plasma levels related to peripheral arterial disease? Results from a cross-sectional study of 6880 primary care patients. Eur J Clin Invest. 2003; 33(9):751-7. DOI: 10.1046/j.1365-2362.2003.01196.x. View

Aronow W . Homocysteine. The association with atherosclerotic vascular disease in older persons. Geriatrics. 2003; 58(9):22-4, 27-8. View

Doshi S, McDowell I, Moat S, Lewis M, Goodfellow J . Folate improves endothelial function in patients with coronary heart disease. Clin Chem Lab Med. 2003; 41(11):1505-12. DOI: 10.1515/CCLM.2003.231. View

Kang S, Wong P, MALINOW M . Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr. 1992; 12:279-98. DOI: 10.1146/annurev.nu.12.070192.001431. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Scragg R, Camargo Jr C, Simpson R . Relation of serum 25-hydroxyvitamin D to heart rate and cardiac work (from the National Health and Nutrition Examination Surveys). Am J Cardiol. 2010; 105(1):122-8. DOI: 10.1016/j.amjcard.2009.08.661. View

Souberbielle J, Body J, Lappe J, Plebani M, Shoenfeld Y, Wang T . Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmun Rev. 2010; 9(11):709-15. DOI: 10.1016/j.autrev.2010.06.009. View

Sun Q, Shi L, Rimm E, Giovannucci E, Hu F, Manson J . Vitamin D intake and risk of cardiovascular disease in US men and women. Am J Clin Nutr. 2011; 94(2):534-42. PMC: 3142728. DOI: 10.3945/ajcn.110.008763. View

10.

Hossein-Nezhad A, Holick M . Vitamin D for health: a global perspective. Mayo Clin Proc. 2013; 88(7):720-55. PMC: 3761874. DOI: 10.1016/j.mayocp.2013.05.011. View

11.

Peterson A . A review of vitamin D and Parkinson's disease. Maturitas. 2014; 78(1):40-4. DOI: 10.1016/j.maturitas.2014.02.012. View

12.

Fyfe I . Parkinson disease. Reduced level of dietary vitamin D is associated with PD. Nat Rev Neurol. 2015; 11(2):68. DOI: 10.1038/nrneurol.2014.265. View

13.

Lee T, Lee T, Chang C, Lien G, Kao Y, Chao T . Potential of vitamin D in treating diabetic cardiomyopathy. Nutr Res. 2015; 35(4):269-79. DOI: 10.1016/j.nutres.2015.02.005. View

14.

Shin M, Kang Y, Kong S, Ju S, Back M, Kim K . A case of low bone mineral density with vitamin d deficiency due to prolonged lactation and severe malnutrition. J Bone Metab. 2015; 22(1):39-43. PMC: 4357636. DOI: 10.11005/jbm.2015.22.1.39. View

15.

He W, Liu M, Huang X, Qing Z, Gao W . The influence of vitamin D receptor genetic variants on bone mineral density and osteoporosis in Chinese postmenopausal women. Dis Markers. 2015; 2015:760313. PMC: 4346683. DOI: 10.1155/2015/760313. View

16.

Wong G, Lim W, Lewis J, Craig J, Turner R, Zhu K . Vitamin D and cancer mortality in elderly women. BMC Cancer. 2015; 15:106. PMC: 4356107. DOI: 10.1186/s12885-015-1112-5. View

17.

Montalescot G, Ankri A, Chadefaux-Vekemans B, Blacher J, Philippe F, Drobinski G . Plasma homocysteine and the extent of atherosclerosis in patients with coronary artery disease. Int J Cardiol. 1997; 60(3):295-300. DOI: 10.1016/s0167-5273(97)00099-5. View

18.

Wilcken D, Wilcken B . The pathogenesis of coronary artery disease. A possible role for methionine metabolism. J Clin Invest. 1976; 57(4):1079-82. PMC: 436752. DOI: 10.1172/JCI108350. View

19.

Sacco R, Roberts J, Jacobs B . Homocysteine as a risk factor for ischemic stroke: an epidemiological story in evolution. Neuroepidemiology. 1998; 17(4):167-73. DOI: 10.1159/000026169. View

20.

Yoo J, Chung C, Kang S . Relation of plasma homocyst(e)ine to cerebral infarction and cerebral atherosclerosis. Stroke. 1998; 29(12):2478-83. DOI: 10.1161/01.str.29.12.2478. View