MiRNA-mRNA Crosstalk in Myocardial Ischemia Induced by Calcified Aortic Valve Stenosis

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2019 Jan 18

PMID 30651404

Citations 12

Authors

Chenyang Duan

Zhezhe Cao

Fuqin Tang

Zhao Jian

Chunshui Liang

Hong Liu

Yingbin Xiao

Liangming Liu

Ruiyan Ma

Affiliations

Soon will be listed here.

Abstract

Aortic valve stenosis is the most common cause of morbidity and mortality in valvular heart disease in aged people. Both microRNA (miRNA) and mRNA are potential targets for the diagnosis and therapeutic intervention of myocardial ischemia induced by calcified aortic valve stenosis (CAVS), with unclear mechanisms. Here, 3 gene expression profiles of 47 male participants were applied to generate shared differentially expressed genes (DEGs) with significant major biological functions. Moreover, 20 hub genes were generated by a Weighted Genes Co-Expression Network Analysis (WGCNA) and were cross-linked to miRNA based on miRanda/miRwalk2 databases. Integrated miRNA/mRNA analysis identified several novel miRNAs and targeted genes as diagnostic/prognostic biomarkers or therapeutic targets in CAVS patients. In addition, the clinical data suggested that myocardial hypertrophy and myocardial ischemia in CAVS patients are likely associated with hub genes and the upstream regulatory miRNAs. Together, our data provide evidence that miRNAs and their targeted genes play an important role in the pathogenesis of myocardial hypertrophy and ischemia in patients with CAVS.

Citing Articles

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