The Cardiovascular Protective Effects of Chrysin: A Narrative Review on Experimental Researches

Overview

Journal Cardiovasc Hematol Agents Med Chem

Publisher Bentham Science Publishers

Specialties Cardiology & Vascular Diseases
Chemistry
Hematology
Pharmacology

Date 2019 Jan 17

PMID 30648526

Citations 14

Authors

Tahereh Farkhondeh

Saeed Samarghandian

Fereshteh Bafandeh

Affiliations

Soon will be listed here.

Abstract

Chrysin is one of the flavonoids fruits, vegetables, and plant especially found in honey, it has been indicated that its cardiovascular protective effect is due to its antioxidative effects and anti inflammatory activities. Chrysin exerts an antioxidant effect by enhancing the antioxidant system, suppressing pro-oxidant enzymes, scavenging free radicals and chelating redox active transition metal ions. Chrysin decreases lipid synthesis and also increases its metabolism, thereby ameliorating blood lipid profile. Chrysin modulates vascular function by increasing the bioavailability of endothelial nitric oxide. Chrysin inhibits the development of atherosclerosis by decreasing vascular inflammation. The anti-inflammatory effects of chrysin may relate to its inhibitory effect on the nuclear transcriptional factor-kB signaling pathway. It also prevents vascular smooth muscle cells proliferation and thrombogenesis. Altogether, chrysin may be effective as a natural agent for the prevention and treatment of cardiovascular diseases; however, several clinical trial studies should be done to confirm its protective effects on humans.

Citing Articles

Anticancer Activity of Ether Derivatives of Chrysin.

Sokal A, Mruczek P, Niedoba M, Dewalska A, Stocerz K, Kadela-Tomanek M Molecules. 2025; 30(4).

PMID: 40005270 PMC: 11857933. DOI: 10.3390/molecules30040960.

Chrysin Attenuates Gentamicin-Induced Renal Injury in Rats Through Modulation of Oxidative Damage and Inflammation via Regulation of Nrf2/AKT and NF-kB/KIM-1 Pathways.

Albukhari T, Bagadood R, Bokhari B, Filimban W, Sembawa H, Nasreldin N Biomedicines. 2025; 13(2).

PMID: 40002685 PMC: 11853687. DOI: 10.3390/biomedicines13020271.

The ameliorative effect of chrysin on ovarian toxicity caused by methidathion in female rats.

Hamed A, Ali F, Mohammed A, Alrasheedi M, Ragab I, Aldoghaim M Front Mol Biosci. 2024; 11:1470711.

PMID: 39669673 PMC: 11635302. DOI: 10.3389/fmolb.2024.1470711.

Eco-Friendly Analytical Approach for Sensitive Spectrofluorimetric Determination of the Flavonoid Chrysin in Capsules and Human Plasma.

El-Aziz H, Hammouda N, Belal F, Elama H J Fluoresc. 2024; .

PMID: 39446181 DOI: 10.1007/s10895-024-03962-9.

Chrysin downregulates the expression of ADAMTS-4 in foam cells.

Aswani S, Jayan S, Mohan M, Aparna N, Boban P, Saja K Mol Biol Rep. 2024; 51(1):968.

PMID: 39249599 DOI: 10.1007/s11033-024-09896-6.

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