Biological Properties of Calcium Phosphate Bioactive Glass Composite Bone Substitutes: Current Experimental Evidence

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Jan 17

PMID 30646516

Citations 30

Authors

Maria Karadjian

Christopher Essers

Stefanos Tsitlakidis

Bruno Reible

Arash Moghaddam

Aldo R Boccaccini

Fabian Westhauser

Affiliations

Soon will be listed here.

Abstract

Standard treatment for bone defects is the biological reconstruction using autologous bone-a therapeutical approach that suffers from limitations such as the restricted amount of bone available for harvesting and the necessity for an additional intervention that is potentially followed by donor-site complications. Therefore, synthetic bone substitutes have been developed in order to reduce or even replace the usage of autologous bone as grafting material. This structured review focuses on the question whether calcium phosphates (CaPs) and bioactive glasses (BGs), both established bone substitute materials, show improved properties when combined in CaP/BG composites. It therefore summarizes the most recent experimental data in order to provide a better understanding of the biological properties in general and the osteogenic properties in particular of CaP/BG composite bone substitute materials. As a result, BGs seem to be beneficial for the osteogenic differentiation of precursor cell populations in-vitro when added to CaPs. Furthermore, the presence of BG supports integration of CaP/BG composites into bone in-vivo and enhances bone formation under certain circumstances.

Citing Articles

Rapid fabrication of biomimetic PLGA microsphere incorporated with natural porcine dermal aECM for bone regeneration.

Zhou X, Guo M, Wang Z, Wang Y, Zhang P Regen Biomater. 2024; 11:rbae099.

PMID: 39463918 PMC: 11512121. DOI: 10.1093/rb/rbae099.

Advancements in incorporating metal ions onto the surface of biomedical titanium and its alloys via micro-arc oxidation: a research review.

Zhang X, Zhou W, Xi W Front Chem. 2024; 12:1353950.

PMID: 38456182 PMC: 10917964. DOI: 10.3389/fchem.2024.1353950.

Effect of Low Copper Doping on the Optical, Cytocompatible, Antibacterial, and SARS-CoV-2 Trapping Properties of Calcium Phosphate Glasses.

Restivo E, Pugliese D, Gallichi-Nottiani D, Sammartino J, Bloise N, Peluso E ACS Omega. 2023; 8(45):42264-42274.

PMID: 38024754 PMC: 10652837. DOI: 10.1021/acsomega.3c04293.

Reduced Sodium Portions Favor Osteogenic Properties and Cytocompatibility of 45S5-Based Bioactive Glass Particles.

Tsitlakidis S, Hohenbild F, Saur M, Moghaddam A, Kunisch E, Renkawitz T Biomimetics (Basel). 2023; 8(6).

PMID: 37887603 PMC: 10604502. DOI: 10.3390/biomimetics8060472.

Synthetic Calcium-Phosphate Materials for Bone Grafting.

Mishchenko O, Yanovska A, Kosinov O, Maksymov D, Moskalenko R, Ramanavicius A Polymers (Basel). 2023; 15(18).

PMID: 37765676 PMC: 10536599. DOI: 10.3390/polym15183822.

References

Hale L, Ma Y, Santerre R . Semi-quantitative fluorescence analysis of calcein binding as a measurement of in vitro mineralization. Calcif Tissue Int. 2000; 67(1):80-4. DOI: 10.1007/s00223001101. View

Moore W, Graves S, Bain G . Synthetic bone graft substitutes. ANZ J Surg. 2001; 71(6):354-61. View

Wiltfang J, Merten H, Schlegel K, Schultze-Mosgau S, Kloss F, Rupprecht S . Degradation characteristics of alpha and beta tri-calcium-phosphate (TCP) in minipigs. J Biomed Mater Res. 2002; 63(2):115-21. DOI: 10.1002/jbm.10084. View

Hinnebusch B, Siddique A, Welles Henderson J, Malo M, Zhang W, Athaide C . Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. Am J Physiol Gastrointest Liver Physiol. 2003; 286(1):G23-30. DOI: 10.1152/ajpgi.00203.2003. View

Xin R, Leng Y, Chen J, Zhang Q . A comparative study of calcium phosphate formation on bioceramics in vitro and in vivo. Biomaterials. 2005; 26(33):6477-86. DOI: 10.1016/j.biomaterials.2005.04.028. View

Giannoudis P, Dinopoulos H, Tsiridis E . Bone substitutes: an update. Injury. 2005; 36 Suppl 3:S20-7. DOI: 10.1016/j.injury.2005.07.029. View

Chen Q, Thompson I, Boccaccini A . 45S5 Bioglass-derived glass-ceramic scaffolds for bone tissue engineering. Biomaterials. 2005; 27(11):2414-25. DOI: 10.1016/j.biomaterials.2005.11.025. View

Boccaccini A, Chen Q, Lefebvre L, Gremillard L, Chevalier J . Sintering, crystallisation and biodegradation behaviour of Bioglass-derived glass-ceramics. Faraday Discuss. 2007; 136:27-44. DOI: 10.1039/b616539g. View

Arnett T . Extracellular pH regulates bone cell function. J Nutr. 2008; 138(2):415S-418S. DOI: 10.1093/jn/138.2.415S. View

10.

Steffens L, Wenger A, Stark G, Finkenzeller G . In vivo engineering of a human vasculature for bone tissue engineering applications. J Cell Mol Med. 2008; 13(9B):3380-6. PMC: 4516493. DOI: 10.1111/j.1582-4934.2008.00418.x. View

11.

Giannoudis P, Einhorn T, Schmidmaier G, Marsh D . The diamond concept--open questions. Injury. 2008; 39 Suppl 2:S5-8. DOI: 10.1016/S0020-1383(08)70010-X. View

12.

Cai S, Xu G, Yu X, Zhang W, Xiao Z, Yao K . Fabrication and biological characteristics of beta-tricalcium phosphate porous ceramic scaffolds reinforced with calcium phosphate glass. J Mater Sci Mater Med. 2008; 20(1):351-8. DOI: 10.1007/s10856-008-3591-2. View

13.

Haimi S, Moimas L, Pirhonen E, Lindroos B, Huhtala H, Raty S . Calcium phosphate surface treatment of bioactive glass causes a delay in early osteogenic differentiation of adipose stem cells. J Biomed Mater Res A. 2008; 91(2):540-7. DOI: 10.1002/jbm.a.32233. View

14.

LeGeros R . Calcium phosphate-based osteoinductive materials. Chem Rev. 2008; 108(11):4742-53. DOI: 10.1021/cr800427g. View

15.

Song I, Caplan A, Dennis J . In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo. J Orthop Res. 2009; 27(7):916-21. DOI: 10.1002/jor.20838. View

16.

Kucukkolbasi H, Mutlu N, Isik K, Celik I, Oznurlu Y . Histological evaluation of the effects of bioglass, hydroxyapatite, or demineralized freeze-dried bone, grafted alone or as composites, on the healing of tibial defects in rabbits. Saudi Med J. 2009; 30(3):329-33. View

17.

Yu X, Cai S, Xu G, Zhou W, Wang D . Low temperature fabrication of high strength porous calcium phosphate and the evaluation of the osteoconductivity. J Mater Sci Mater Med. 2009; 20(10):2025-34. DOI: 10.1007/s10856-009-3764-7. View

18.

Hesaraki S, Safari M, Shokrgozar M . Composite bone substitute materials based on beta-tricalcium phosphate and magnesium-containing sol-gel derived bioactive glass. J Mater Sci Mater Med. 2009; 20(10):2011-7. DOI: 10.1007/s10856-009-3783-4. View

19.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009; 6(7):e1000100. PMC: 2707010. DOI: 10.1371/journal.pmed.1000100. View

20.

Deschaseaux F, Sensebe L, Heymann D . Mechanisms of bone repair and regeneration. Trends Mol Med. 2009; 15(9):417-29. DOI: 10.1016/j.molmed.2009.07.002. View