Association of and Polymorphisms with Endometrial Polyp Risk

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2019 Jan 16

PMID 30643822

Authors

Pedro Leopoldo Silva Doria

Thomas Moscovitz

Marcos Tcherniakovsky

Cesar Eduardo Fernandes

Luciano Melo Pompei

Milton Wajman

Angela van Nimwegen

Sergio Haimovich

Affiliations

Soon will be listed here.

Abstract

Introduction: Insulin-like growth factor 1 is a peptide growth factor that promotes cell proliferation and inhibits apoptosis. The bioavailability of is regulated by the insulin-like growth factor binding protein 3 Genetic variations influence the levels of and . The purpose of this study was to examine the association of polymorphisms and with risk of endometrial polyps.

Materials And Methods: Case control observational study, composed of 104 women with antecedent of endometrial polyp (case group) and 81 postmenopausal women without antecedent of endometrial diseases (control group). Genotyping of was performed by PCR and fragment analysis by capillary electrophoresis, and genotyping of was performed by PCR-HRM. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression.

Results: The genotype was associated with an increased endometrial polyp risk (OR=2,57; IC 95%= 1,09 - 6,01); this was also found when combining it with genotypes (OR=2,18; IC 95%= 1,06-4,47). The analyses showed the genotype having a protective effect for endometrial polyp (OR=0,37; IC 95%= 0,19-0,73), fact also observed when grouping and carriers (OR=0,51; IC 95%= 0,28-0,93).

Conclusion: The genotypes and + of the may be considered a risk for endometrial polyp, whereas the genotypes and + of polymorphism have an inverse effect of endometrial polyp risk.

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