Effects of Zoledronic Acid and Vitamin E on Surgical- Induced Osteonecrosis of the Femoral Head in Rabbit

Overview

Journal Arch Bone Jt Surg

Date 2019 Jan 15

PMID 30637311

Citations 1

Authors

Kaveh Gharanizadeh

Sina Aminizadeh

Nima Molavi

Amir Darbandi

Shabnam Nadjafi

Mahsa Fadavighaffari

Tina Shooshtarizadeh

Affiliations

Soon will be listed here.

Abstract

Background: Femoral head osteonecrosis is a progressive disease with disabling outcomes in hip joint if not treated. This study was designed to compare the effects of zoledronic acid plus vitamin E versus zoledronic acid alone in surgical induced femoral head osteonecrosis in rabbits.

Methods: 26 Japanese white adult normal male rabbits at 28-32 weeks old were undertaken surgical femoral dislocation to devastate the femoral neck vessels; the femoral neck vessels were ligated and the hip was relocated. Next, the first 10 rabbits received zoledronic acid injections at 1 and the 4 weeks; the second group (10 rabbits) received zoledronic acid injections at 1 and the 4 week along with daily oral vitamin E for 12 weeks; and the third group was considered as non-treated control group. Radiographic and postmortem pathological assessments including the Ficat classification, epiphyseal quotient (EQ), new bone formation, and residual necrotic bone (RNB) were performed and compared after week 12.

Results: A significant difference was found between the combination therapy group and the control group in Ficat classification at 12 weeks (), but, the difference between monotherapy and combination therapy groups at 12 weeks was nonsignificant (). Also, both treated groups had significant difference with the control group for RNB (). There were no significant differences between the three groups for Ficat classification at the 6 week (); EQ at 6 () and 12 week (); and NBF ().

Conclusion: Although zoledronic acid therapy along with vitamin E could improve some radiologic and pathological indices related to femoral head osteonecrosis, vitamin E showed a relative impact.

Level Of Evidence: I.

Citing Articles

Local administration of zoledronic acid prevents traumatic osteonecrosis of the femoral head in rat model.

Zhao J, Yue T, Lu S, Meng H, Lin Q, Ma H J Orthop Translat. 2021; 27:132-138.

PMID: 33786320 PMC: 7972932. DOI: 10.1016/j.jot.2020.08.005.

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