Occupational Exposure to Styrene and Its Relation with Urine Mandelic Acid, in Plastic Injection Workers

Overview

Journal Environ Monit Assess

Publisher Springer

Specialty Environmental Health

Date 2019 Jan 13

PMID 30635735

Citations 10

Authors

Mahmoud Mohamadyan

Mahmood Moosazadeh

Absalte Borji

Narges Khanjani

Somayeh Rahimi Moghadam

Affiliations

Soon will be listed here.

Abstract

Plastic injection industry workers are exposed to toxic gases and vapors, including styrene. This study aimed to measure exposure to styrene and its relation with urine mandelic acid among plastics injection workers of the electrical parts industry. This descriptive and analytical cross-sectional study was carried out in the plastic injection halls of the electronics industry, in winter 2017 and spring 2018. Styrene gas in the workers' respiratory region was sampled by the NIOSH 1501 method and was analyzed by gas chromatography-mass spectrometry (GC/MAS). Mandelic acid concentration was determined by high-performance liquid chromatography (HPLC). Statistical data analysis was performed with STATA11. The mean of age and working experience in the population under study were 32.4 ± 8.1 and 6.4 ± 5 years, respectively. The average exposure to styrene was 83.2 ± 32.4 mg·m and the mean of urine mandelic acid was 1570.1 ± 720.6 mg·g ceratinine. There were 24 workers (45.3%) exposed to levels above permissible limits recommended by national and international organizations. There was a positive and significant correlation between exposure to styrene and urine mandelic acid (P = 0.006, r = 0.4). In multivariate regression, occupational exposure to styrene (P = 0.002, β = 0.5) was the strongest variable, predicting the amount of urine mandelic acid. Increased occupational exposure to styrene increases mandelic acid in the urine, and applying control measures to reduce exposure to styrene vapor is recommended in high exposure situations.

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References

Prieto M, Marhuenda D, Cardona A . Analysis of styrene and its metabolites in blood and urine of workers exposed to both styrene and acetone. J Anal Toxicol. 2002; 26(1):23-8. DOI: 10.1093/jat/26.1.23. View

Engstrom K, Harkonen H, Kalliokoski P, Rantanen J . Urinary mandelic acid concentration after occupational exposure to styrene and its use as a biological exposure test. Scand J Work Environ Health. 1976; 2(1):21-6. DOI: 10.5271/sjweh.2825. View

Thompson R, Swan S, Moore C, Vom Saal F . Our plastic age. Philos Trans R Soc Lond B Biol Sci. 2009; 364(1526):1973-6. PMC: 2874019. DOI: 10.1098/rstb.2009.0054. View

Andrady A, Neal M . Applications and societal benefits of plastics. Philos Trans R Soc Lond B Biol Sci. 2009; 364(1526):1977-84. PMC: 2873019. DOI: 10.1098/rstb.2008.0304. View

Thompson R, Moore C, Vom Saal F, Swan S . Plastics, the environment and human health: current consensus and future trends. Philos Trans R Soc Lond B Biol Sci. 2009; 364(1526):2153-66. PMC: 2873021. DOI: 10.1098/rstb.2009.0053. View

Sorsa M, Anttila A, Jarventaus H, Kubiak R, Norppa H, Nylander L . Styrene revisited--exposure assessment and risk estimation in reinforced plastics industry. Prog Clin Biol Res. 1991; 372:187-95. View

Polakova M, Krajcovicova Z, Melus V, Stefkovicova M, Sulcova M . Study of urinary concentrations of mandelic acid in employees exposed to styrene. Cent Eur J Public Health. 2013; 20(3):226-32. DOI: 10.21101/cejph.a3649. View

Ghotbi M, Khanjani N, Barkhordari A, Rahimi Moghadam S, Mozaffari A, Gozashti M . Changes in urinary catecholamines in response to noise exposure in workers at Sarcheshmeh Copper Complex, Kerman, Iran. Environ Monit Assess. 2013; 185(11):8809-14. DOI: 10.1007/s10661-013-3213-4. View

Barkhordari A, Barzegar S, Hekmatimoghaddam H, Jebali A, Rahimi Moghadam S, Khanjani N . The toxic effects of silver nanoparticles on blood mononuclear cells. Int J Occup Environ Med. 2014; 5(3):164-8. PMC: 7767596. View

10.

Barkhordari A, Jones C, Stoddart R, McClure S, McClure J, Rahimi Moghadam S . The glycoprofile patterns of endothelial cells in usual interstitial pneumonia. Int J Occup Environ Med. 2014; 5(4):201-7. PMC: 7767608. View

11.

Bond J . Review of the toxicology of styrene. Crit Rev Toxicol. 1989; 19(3):227-49. DOI: 10.3109/10408448909037472. View

12.

Rahimi Moghadam S, Abedi S, Afshari M, Abedini E, Moosazadeh M . Decline in lung function among cement production workers: a meta-analysis. Rev Environ Health. 2017; 32(4):333-341. DOI: 10.1515/reveh-2017-0017. View

13.

SOLLENBERG J, Bjurstrom R, Wrangskog K, Vesterberg O . Biological exposure limits estimated from relations between occupational styrene exposure during a workweek and excretion of mandelic and phenylglyoxylic acids in urine. Int Arch Occup Environ Health. 1988; 60(5):365-70. DOI: 10.1007/BF00405672. View

14.

LeMasters G, Carson A, Samuels S . Occupational styrene exposure for twelve product categories in the reinforced-plastics industry. Am Ind Hyg Assoc J. 1985; 46(8):434-41. DOI: 10.1080/15298668591395120. View

15.

Ikeda M, Imamura T, Hayaskh M, Tabuchi T, Hara I . Evaluation of hippuric, phenylglyoxylic and mandelic acids in urine as indices of styrene exposure. Int Arch Arbeitsmed. 1974; 32(1):93-101. DOI: 10.1007/BF00539099. View

16.

Elia V, Anderson L, MacDonald T, Carson A, Buncher C, Brooks S . Determination of urinary mandelic and phenylglyoxylic acids in styrene exposed workers and a control population. Am Ind Hyg Assoc J. 1980; 41(12):922-6. DOI: 10.1080/15298668091425879. View

17.

Severi M, Pauwels W, Van Hummelen P, Roosels D, Kirsch-Volders M, Veulemans H . Urinary mandelic acid and hemoglobin adducts in fiberglass-reinforced plastics workers exposed to styrene. Scand J Work Environ Health. 1994; 20(6):451-8. DOI: 10.5271/sjweh.1375. View

18.

Chua S, Lee B, Liau L, Ong C . Determination of mandelic acid and phenylglyoxylic acid in the urine and its use in monitoring of styrene exposure. J Anal Toxicol. 1993; 17(3):129-32. DOI: 10.1093/jat/17.3.129. View