Sepsis Associated Acute Kidney Injury

Overview

Journal BMJ

Specialty General Medicine

Date 2019 Jan 11

PMID 30626586

Citations 342

Authors

Jason T Poston

Jay L Koyner

Affiliations

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Abstract

Sepsis is defined as organ dysfunction resulting from the host's deleterious response to infection. One of the most common organs affected is the kidneys, resulting in sepsis associated acute kidney injury (SA-AKI) that contributes to the morbidity and mortality of sepsis. A growing body of knowledge has illuminated the clinical risk factors, pathobiology, response to treatment, and elements of renal recovery that have advanced our ability to prevent, detect, and treat SA-AKI. Despite these advances, SA-AKI remains an important concern and clinical burden, and further study is needed to reduce the acute and chronic consequences. This review summarizes the relevant evidence, with a focus on the risk factors, early recognition and diagnosis, treatment, and long term consequences of SA-AKI. In addition to literature pertaining to SA-AKI specifically, pertinent sepsis and acute kidney injury literature relevant to SA-AKI was included.

Citing Articles

Elevated IAP in critically ill patients associated with increased AKI incidence: a cohort study from the MIMIC-IV database.

Miao S, Yang M, Li W, Yan J Sci Rep. 2025; 15(1):8245.

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Biomarkers of cell cycle arrest, microcirculation dysfunction, and inflammation in the prediction of SA-AKI.

Zhang Q, Yang B, Li X, Zhao Y, Yang S, Ma Q Sci Rep. 2025; 15(1):8023.

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Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury.

Chen L, Deng Y, Hu J, Gong X Front Pharmacol. 2025; 16:1539886.

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Association between the lactate-to-albumin ratio (LAR) index and risk of acute kidney injury in critically ill patients with sepsis: analysis of the MIMIC-IV database.

Hua Y, Ding N, Jing H, Xie Y, Wu H, Wu Y Front Physiol. 2025; 16:1469866.

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Occurrence rate and risk factors for acute kidney injury after lung transplantation: a systematic review and meta-analysis.

Lee N, Ying H PeerJ. 2025; 13:e18364.

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